Genetic Risk Outweighs Age: Machine Learning Models Rank Predictive Risks for Alzheimer’s Disease

Alzheimer’s disease, a progressive neurological disorder, is the most common form of dementia affecting millions of people worldwide. This devastating condition erodes memory, cognitive abilities, and eventually the ability to perform daily tasks. Although primarily associated with aging, Alzheimer’s has a complex interplay of genetic, environmental, and lifestyle factors.

Research indicates that genetic predisposition supersedes age as a risk factor in adults above 65.

According to a recent study, once individuals reach the age of 65, which is the threshold for the onset of Alzheimer’s disease, their genetic risk may play a larger role in determining if they will develop the fatal brain disorder, as opposed to just their age.

The study, recently published recently in the journal Scientific Reports, utilized machine learning models to rank risk factors for developing Alzheimer’s disease. This was achieved by using genetic risk scores, non-genetic information, and electronic health record data from nearly half a million individuals. This study is the first of its kind to combine these data sources and rank risk factors based on their strength of association with Alzheimer’s disease.

Researchers used the models to rank predictive risk factors for two populations from the UK Biobank: White individuals aged 40 and older, and a subset of those adults who were 65 or older.

Results showed that age – which constitutes one-third of total risk by age 85, according to the Alzheimer’s Association – was the biggest risk factor for Alzheimer’s in the entire population, but for the older adults, genetic risk as determined by a polygenic risk score was more predictive.

“We all know Alzheimer’s disease is a later-onset disease, so we know age is an important risk factor. But when we consider risk only for people age 65 or older, then genetic information captured by a polygenic risk score ranks higher than age,” said lead study author Xiaoyi Raymond Gao, associate professor of ophthalmology and visual sciences and of biomedical informatics in The Ohio State University College of Medicine. “That means it’s really important to consider genetic information when we work on Alzheimer’s disease.”

A low household income also emerged as an important risk factor, ranking either third or fourth after the effects of age and genetics.

“The finding related to income is very, very interesting,” said Gao, also a member of Ohio State’s Division of Human Genetics faculty, whose lab uses biomedical big data and artificial intelligence to study the genetics behind Alzheimer’s and ocular diseases. “We all want to have a healthy life, and income can be such an important factor to decide what you can afford to eat, where you can afford to live, education level, access to care – and all of these possibly contribute to Alzheimer’s disease.”

Of the 457,936 UK Biobank participants in the sample, 2,177 individuals had developed Alzheimer’s disease and 455,759 had not, and 88,309 were 65 or older.

A few non-genetic risk factors that differed between people with and without Alzheimer’s disease (AD) stood out: Results showed that in people with AD, higher systolic and lower diastolic blood pressure were more common, diabetes was more prevalent, household income and education were lower, and recent falls, hearing difficulty and a mother’s history of having AD were higher.

The top-20 list of risk factors for the full sample of adults also included diagnoses of high blood pressure, urinary tract infection, depressive episodes, fainting, unspecified chest pain, disorientation, and abnormal weight loss. Other risk factors in the top 20 for people 65 and older included high cholesterol and gait abnormalities. These findings showed the power of adding condition codes from electronic health records to the models.

“Machine learning can explore relationships among all of those features, or variables, pick the important features and rank certain features at the top that contribute much more to Alzheimer’s disease risk than the rest of the features,” Gao said. “Typically, it’s not good to be highly obese, but we also see here that a lower body mass index is not good. High blood pressure is typically not good, but here we see lower diastolic blood pressure is not good. The models revealed some interesting patterns.”

Building the models was a two-step process. The team first conducted genome-wide association studies using data from the Alzheimer’s Disease Genetics Consortium to identify genetic variants linked to the overall risk of developing Alzheimer’s disease and to the development of the disease after a specific age. The separate collections of variants were used to establish two polygenic risk scores, which aggregate genetic effects across the genome into a single measure of risk for each individual.

Those scores were applied to DNA data from the UK Biobank participants and combined with biobank information on conventional risk factors such as sex, education, body mass index, and blood pressure, and more than 11,000 electronic health record condition codes that had been cited in individuals’ records.

The team also used an algorithm in interpreting the model’s output to ensure risk factor variables were weighted objectively in the analysis.

We are born with our genetic risk for disease already established, but information about how other health and socioeconomic factors affect our risk for Alzheimer’s – as well as glaucoma, which Gao also studies – gives us the power to take preventive measures, he said.

“If people know more about risk factors, they can possibly adjust their lifestyle. For both Alzheimer’s and glaucoma, there is no cure, so prevention can help a lot,” Gao said. “I also hope constructing models to make these predictions could help with drug development and effective and low-cost screening programs.”

Reference: “Explainable machine learning aggregates polygenic risk scores and electronic health records for Alzheimer’s disease prediction” by Xiaoyi Raymond Gao, Marion Chiariglione, Ke Qin, Karen Nuytemans, Douglas W. Scharre, Yi-Ju Li, and Eden R. Martin, 9 January 2023, Scientific Reports.
DOI: 10.1038/s41598-023-27551-1