Meat vs. Plant: New Research Reveals a Clear Winner for Muscle Growth

Red Meat Two Steaks

Recent research demonstrates that omnivorous meals with lean beef lead to higher muscle protein synthesis than vegan meals with equal protein content, highlighting the importance of protein source selection for muscle maintenance in older adults.

Evidence contributes to the expanding body of research that indicates protein food sources are essential for building and maintaining muscle.

Extensive studies have demonstrated that the intake of dietary protein plays a crucial role in promoting muscle protein synthesis, a key element in the development and upkeep of skeletal muscle mass. Recent findings suggest a significant difference between animal-based and plant-based protein sources regarding their effectiveness in stimulating muscle growth and maintenance. This disparity is largely attributed to variations in the protein quantity and quality, as well as the differing levels of essential amino acids (EAA) present in these food sources.

Comparative Study on Protein Sources

New research recently published in the Journal of Nutrition is one of the first randomized controlled trials to compare the anabolic properties of whole protein foods when consumed as part of mixed meals. The study found that, despite having the same caloric and total protein contents, a whole-food omnivorous meal with lean beef resulted in greater postprandial muscle protein synthesis rates than a whole-food vegan meal in older adults. In fact, researchers observed a 47% higher muscle protein synthesis rate following consumption of the omnivorous meal with lean beef, compared with the whole food vegan meal that provided an equal amount of protein from plants.

“While studies have previously assessed the impact of consuming isolated proteins, this research aims to mirror a more real-life setting by understanding the effects of eating whole protein foods as part of a typical meal,” said Luc van Loon, Ph.D., professor of Physiology of Exercise and Nutrition, Department of Human Biology, Maastricht University Medical Center, and principal investigator of the research study. “Given the importance of protecting lean body mass to maintain strength as we age and the growing interest in vegetarian and vegan lifestyles, this research is important to understand if protein food sources can be equally effective in supporting muscle maintenance and growth.”

Based on previous research comparing the ingestion of different protein sources, the researchers were able to calculate that 16 participants would be needed to complete the study and detect a potential difference in muscle protein synthesis rates following ingestion of the two meals. Accordingly, the clinical trials were conducted with 16 healthy, older adults (ages 65-85 years), in Maastricht, the Netherlands. On one test day, the participants ate a whole food omnivorous meal containing 3.5 ounces of lean ground beef as the primary source of protein, with potatoes, string beans, applesauce (made of 100% apples), and herb butter.

The other test day included eating a whole-food vegan meal of equal caloric and protein content, comprised of unprocessed, commonly consumed plant protein foods such as quinoa, soybeans, chickpeas, and broad beans, as the main ingredients. Importantly, both meals contained on average 36 grams of protein, which is aligned with evidence-based recommendations for stimulating muscle protein synthesis in older individuals (i.e., 0.45 g protein per kg body weight).

“We were interested in studying the impact of meal consumption on muscle protein synthesis in older adults given the significance of age-related loss of muscle mass and strength, known as sarcopenia, which is a growing public health concern globally,” added van Loon.

Study Findings and Implications

All participants refrained from sports and strenuous physical activities, as well as alcohol consumption, for two days prior to each of the two experimental trial days. Researchers compared post-meal plasma amino acid profiles and muscle protein synthesis rates, using blood and muscle biopsies that were collected frequently for six hours following meal ingestion. In addition to observing the 47% increased muscle protein synthesis rate over a 6-hour postprandial period, researchers noted plasma EAA concentrations were 127% higher following the lean beef meal, despite the vegan meal not presenting any selective amino acid deficiencies.

“Importantly, plasma leucine, which is an essential amino acid particularly important for muscle protein synthesis, was 139% higher in participants, after they ate the omnivorous beef-containing meal,” said Philippe Pinckaers, MSc., lead author of the publication. “While more research is needed over a longer timeframe, this study illustrates the potential impact of the food matrix and significance of amino acid bioavailability and biofunctionality differences between beef-containing and vegan meals.”

Reference: “Higher Muscle Protein Synthesis Rates Following Ingestion of an Omnivorous Meal Compared with an Isocaloric and Isonitrogenous Vegan Meal in Healthy, Older Adults” by Philippe JM Pinckaers, Jacintha Domić, Heather L Petrick, Andrew M Holwerda, Jorn Trommelen, Floris K Hendriks, Lisanne HP Houben, Joy PB Goessens, Janneau MX van Kranenburg, Joan M Senden, Lisette CPGM de Groot, Lex B Verdijk, Tim Snijders and Luc JC van Loon, 15 November 2023, The Journal of Nutrition.
DOI: 10.1016/j.tjnut.2023.11.004

The study was funded by the Beef Checkoff, through the National Cattlemen’s Beef Association, which was not involved in the study design, interpretation, or publication. 

12 Comments on "Meat vs. Plant: New Research Reveals a Clear Winner for Muscle Growth"

  1. Eat meat! Just like our cavepeople ancestors did.

  2. “doubt”, sorry, can’t help it when I look at the funders.

  3. My oncological dietician wants cancer patients to eat meat protein as it is utilized more effectively than plant based protein. I eat a mixture of meat based and plant based.

  4. Says it all: “The study was funded by the Beef Checkoff, through the National Cattlemen’s Beef Association”.

    Funny how beef-industry funded studies always show beef is better than plant based proteins.

    How about making sure that you compare people who normally eat a vegetarian diet and are tus more ready to process the plant proteins than an omnivore.

    • Also make sure that the amino acids are the same per diet… Most body builders take protein supplements anyway, not sure this is relevant for normal people.

    • There is no “better” protein.
      Plant and meat based proteins are distinctly different and offer their own set of benefits and drawbacks.

      The worst thing you could do is limit your diet to one type of protein.

  5. Wim de Villiers | January 23, 2024 at 2:44 pm | Reply

    Why lean meat. The body needs fat.

  6. Muhammad Khalid Butt | January 24, 2024 at 8:27 am | Reply


  7. Also, why didn’t you lose the jargon and give us laymen a conclusion that doesn’t read like Chinese.

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