A study reveals that the OSER1 protein significantly impacts longevity, suggesting new treatment possibilities for aging.
A new study from the University of Copenhagen reveals that a specific gene plays a significant role in determining longevity, potentially opening the door to new treatments.
Sleep, fasting, exercise, green porridge, black coffee, a healthy social life…
There is an abundance of advice out there on how to live a good, long life. Researchers are working hard to determine why some people live longer than others, and how we get the most out of our increasingly long lives.
Now researchers from the Center for Healthy Aging, Department of Cellular and Molecular Medicine at the University of Copenhagen have made a breakthrough. They have discovered that a particular protein known as OSER1 has a great influence on longevity.
”We identified this protein that can extend longevity (long duration of life, red.). It is a novel pro-longevity factor, and it is a protein that exists in various animals, such as fruit flies, nematodes, silkworms, and in humans,” says Professor Lene Juel Rasmussen, senior author behind the new study.
Because the protein is present in various animals, the researchers conclude that new results also apply to humans:
”We identified a protein commonly present in different animal models and humans. We screened the proteins and linked the data from the animals to the human cohort also used in the study. This allows us to understand whether it is translatable into humans or not,” says Zhiquan Li, who is a first author behind the new study and adds:
“If the gene only exists in animal models, it can be hard to translate to human health, which is why we, in the beginning, screened the potential longevity proteins that exist in many organisms, including humans. Because at the end of the day, we are interested in identifying human longevity genes for possible interventions and drug discoveries.”
Paves the way for new treatment
The researchers discovered OSER1 when they studied a larger group of proteins regulated by the major transcription factor FOXO, known as a longevity regulatory hub.
“We found 10 genes that, when – we manipulated their expression – longevity changed. We decided to focus on one of these genes that affected longevity most, called the OSER1 gene,” says Zhiquan Li.
When a gene is associated with shorter a life span, the risk of premature aging and age-associated diseases increases. Therefore, knowledge of how OSER1 functions in the cells and preclinical animal models is vital to our overall knowledge of human aging and human health in general.
“We are currently focused on uncovering the role of OSER1 in humans, but the lack of existing literature presents a challenge, as very little has been published on this topic to date. This study is the first to demonstrate that OSER1 is a significant regulator of aging and longevity. In the future, we hope to provide insights into the specific age-related diseases and aging processes that OSER1 influences,” says Zhiquan Li.
The researchers also hope that the identification and characterization of OSER1 will provide new drug targets for age-related diseases such as metabolic diseases, cardiovascular and neurodegenerative diseases.
“Thus, the discovery of this new pro-longevity factor allows us to understand longevity in humans better,” says Zhiquan Li.
Reference: “FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species” by Jiangbo Song, Zhiquan Li, Lei Zhou, Xin Chen, Wei Qi Guinevere Sew, Héctor Herranz, Zilu Ye, Jesper Velgaard Olsen, Yuan Li, Marianne Nygaard, Kaare Christensen, Xiaoling Tong, Vilhelm A. Bohr, Lene Juel Rasmussen and Fangyin Dai, 21 August 2024, Nature Communications.
DOI: 10.1038/s41467-024-51542-z
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9 Comments
Secret to Longevities. As I said before. Human being is a perfect Specimen. Thanks to our Creator. But we are a disappointed to our Creator. We do Dum and Stupid things. We surposses to be better than Dinosaurs. During the Dinosaur times there no Doctors and Scientists, and they survived. They only kills themselves for Food, Human being kills themselves for Fun. For stupid reasons and for our unforced Error. To live for long time we have to be using our Common sense. Like stopping or reduce the using of all this Soaps or chemicals that is dangerous and damaging to your body and your DNA. And the soap or chemicals are coursing Sickness and Deasesses like Cancer to your body and your DNA. Smoking Weed, smoking Sigret, drink Wine or bear in modrate can not kills you. You can drink and smoke, they are allowed. More than 50 percent of What is killing you is the chemicals / soap = Poison you are using every day. Thanks. To be continued. M. Luke.
As I said before, many Many Men and women lost their lives for unforced Error or man made ignorance. Take for example 50 percent of men that lost their hair are lost because of washing there hair every every day with chemicals. The chemicals and soap make your body and your DNA acceptable to Sickness and Deasesses. Make you fragile. Stay away from Dum things. You May have chances of Surviving for long time.
I know you don’t know that you surposses to come to this Planet or this World and survived anything else is Problems for individuals. You have to live at least 100 years anything other than that you are in trouble and you are in problems. I know you don’t know what is awaything you if you Die Young. You have to Survives that’s your first mission. The rest is Luxuries. What you do while you are on Earth, you will answer for it. Thanks. To be continued. M. Luke.
Michael Luke, your comments are not helpful and are ruining the comment section. Maybe that is your intent. You don’t seem real, and may just be trying to destroy the comment section to prevent intelligent comments from being made.
I concur. M. Luke’s comments are not helping the discussion.
Yes, this is either a bot or a moron. My suspicion that it’s a bot programmed to be prolific and consistently trained on a corpus of moronic materials so as to seem consistent. Few morons actually have enough time and energy to output this content, as they have to get back work mowing the lawn for the church parish.
As I said before, many Many Men and women lost their lives for unforced Error or man made ignorance. Take for example 50 percent of men that lost their hair are lost because of washing there hair every every day with chemicals. The chemicals and soap make your body and your DNA acceptable to Sickness and Deasesses. Make you fragile. Stay away from Dum things. You May have chances of Surviving for long time. Thanks. M. Luke.
The key to longevity is NOT in a nuclear gene or their proteins.
Otherwise it could easily be misfolded, among other things.
Just more folks focused on pharmaceuticals and profiting off humanity’s suffering rather than actually helping.
These type of articles are getting annoying. We’ve been these empty promises for years. Until there is something tangible, keep these fantasy articles to yourself.