The new compound called ERX-41 kills a broad spectrum of hard-to-treat cancers.
A new molecule created by a researcher at the University of Texas at Dallas kills a variety of difficult-to-treat cancers, including triple-negative breast cancer, by taking advantage of a weakness in cells that was not previously targeted by existing drugs.
The research, which was conducted using isolated cells, human cancer tissue, and mouse-grown human cancers, was recently published in Nature Cancer.
A co-corresponding author of the study and an associate professor of chemistry and biochemistry in the School of Natural Sciences and Mathematics at the University of Texas at Dallas, Dr. Jung-Mo Ahn has dedicated more than ten years of his career to developing small molecules that target protein-protein interactions in cells. He previously created potential therapeutic candidate compounds for treatment-resistant prostate cancer and breast cancer using a method called structure-based rational drug design.
In the current work, Ahn and his colleagues tested a novel compound he synthesized called ERX-41 for its effects against breast cancer cells, both those that contain estrogen receptors (ERs) and those that do not. While there are effective treatments available for patients with ER-positive breast cancer, there are few treatment options for patients with triple-negative breast cancer (TNBC), which lacks receptors for estrogen, progesterone, and human epidermal growth factor 2. TNBC generally affects women under 40 and has poorer outcomes than other types of breast cancer.
“The ERX-41 compound did not kill healthy cells, but it wiped out tumor cells regardless of whether the cancer cells had estrogen receptors,” Ahn said. “In fact, it killed the triple-negative breast cancer cells better than it killed the ER-positive cells.
“This was puzzling to us at the time. We knew it must be targeting something other than estrogen receptors in the TNBC cells, but we didn’t know what that was.”
To investigate the ERX-41 molecule, Ahn worked with collaborators, including co-corresponding authors Dr. Ganesh Raj, professor of urology and pharmacology at the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center, as well as Dr. Ratna Vadlamudi, professor of obstetrics and gynecology at UT Health San Antonio. Dr. Tae-Kyung Lee, a former UTD research scientist in Ahn’s Bio-Organic/Medicinal Chemistry Lab, was involved in synthesizing the compound.
The researchers discovered that ERX-41 binds to a cellular protein called lysosomal acid lipase A (LIPA). LIPA is found in a cell structure called the endoplasmic reticulum, an organelle that processes and folds proteins.
“For a tumor cell to grow quickly, it has to produce a lot of proteins, and this creates stress on the endoplasmic reticulum,” Ahn said. “Cancer cells significantly overproduce LIPA, much more so than healthy cells. By binding to LIPA, ERX-41 jams the protein processing in the endoplasmic reticulum, which becomes bloated, leading to cell death.”
The research team also tested the compound in healthy mice and observed no adverse effects.
“It took us several years to chase down exactly which protein was being affected by ERX-41. That was the hard part. We chased many dead ends, but we did not give up,” Ahn said.
“Triple-negative breast cancer is particularly insidious — it targets women at younger ages; it’s aggressive, and it’s treatment-resistant. I’m really glad we’ve discovered something that has the potential to make a significant difference for these patients.”
The researchers fed the compound to mice with human forms of cancerous tumors, and the tumors got smaller. The molecule also proved effective at killing cancer cells in human tissue gathered from patients who had their tumors removed.
They also found that ERX-41 is effective against other cancer types with elevated endoplasmic reticulum stress, including hard-to-treat pancreatic and ovarian cancers and glioblastoma, the most aggressive and lethal primary brain cancer.
“As a chemist, I am somewhat isolated from patients, so this success is an opportunity for me to feel like what I do can be useful to society,” Ahn said.
Reference: “Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress” by Xihui Liu, Suryavathi Viswanadhapalli, Shourya Kumar, Tae-Kyung Lee, Andrew Moore, Shihong Ma, Liping Chen, Michael Hsieh, Mengxing Li, Gangadhara R. Sareddy, Karla Parra, Eliot B. Blatt, Tanner C. Reese, Yuting Zhao, Annabel Chang, Hui Yan, Zhenming Xu, Uday P. Pratap, Zexuan Liu, Carlos M. Roggero, Zhenqiu Tan, Susan T. Weintraub, Yan Peng, Rajeshwar R. Tekmal, Carlos L. Arteaga, Jennifer Lippincott-Schwartz, Ratna K. Vadlamudi, Jung-Mo Ahn, and Ganesh V. Raj, 2 June 2022, Nature Cancer.
Ahn is a joint holder of patents issued and pending on ERX-41 and related compounds, which have been licensed to the Dallas-based startup EtiraRX, a company co-founded in 2018 by Ahn, Raj, and Vadlamudi. The company recently announced that it plans to begin clinical trials of ERX-41 as early as the first quarter of 2023.
The study was funded by the National Cancer Institute, the Cancer Prevention and Research Institute of Texas, and The Welch Foundation.
Hi! Im currently battling with metastatic breast cancer. Please help. Thank you
Wow this is amazing news my sis in law is triple negative survived twice probably has it again … She figured this one would be a death sentence. MAYBE THERES HOPE? AMAZING NEWS CANT WAIT TO TELL HER! THANKS!
I’m 54 with stage 4 breast cancer Mets to the bones. Thank you for trying to save lives!
Trying to deal with ovarian cancer..please help..Thank you
I’m so sorry to hear your diagnosis! I never comment but I had to comment jst to tell you, I love you and be strong n faithful! Easier said than done but I am with u in Spirit! God bless you!
I’m a triple negative survivor. Please continue to work on this!
I wish clinical trials for cancer would not take soo long! Is there anyway to have this process sped up as it was for covid vaccines!? This is great news and great work. Maybe 1 day the process for cancer treatments will speed up.
Are there any human trials available? I’m battling glioblastoma and would love to be around for my 2 year old daughter a lot longer
Please let the researchers try this on tuberous sclerosis complex patients. They can grow tumours their whole lives in critical organs. This compound could be a game changer for the brain tumours!
Cool that Dr. Ahn and his collaborators have patented and licensed the compound to a company they (apparently) retain ownership of. Glad they were able to line up the funding for their years of research. Gratitude to their funders and supporters including their families and mentors.
I have brain cancer the most aggressive kind and I have two small children I care for and I need help I just received my diagnosis the 26 please help me
This is the best news I’ve had all year! Hope we don’t have to wait too long!
I have incurable NSCL Cancer, Mets to the bones, spine and brain. I’ll be your guinea pig!!!
“Ahn is a joint holder of patents issued and pending on ERX-41 and related compounds, which have been licensed to the Dallas-based startup EtiraRX, a company co-founded in 2018 by Ahn, Raj, and Vadlamudi. The company recently announced that it plans to begin clinical trials of ERX-41 as early as the first quarter of 2023.
“The study was funded by the National Cancer Institute, the Cancer Prevention and Research Institute of Texas, and The Welch Foundation.”
Will the for-profit company reimburse those who funded the research therefore making it possible? Or is that viewed a “free money” by the profits over life itself industry?
“Tom Goddu | August 28, 2022 at 12:38 am | Reply
“Cool that Dr. Ahn and his collaborators have patented and licensed the compound to a company they (apparently) retain ownership of. Glad they were able to line up the funding for their years of research. Gratitude to their funders and supporters including their families and mentors.”
Will Ahn’s for-profit company reimburse those who provided the research funding? Or is that viewed as “free money” by the profits-over-life-itself industry.
You are aware that this solution, if approved as a treatment, will take years to “trickle down” to the mass of unmonied, correct?
As someone currently fighting breast cancer this article is so uplifting! Thank you for your diligence in research.
Sister recently diagnosed with metastasized triple negative breast cancer. Starting chemo Sept 12th.
How do we become eligible for ERX-41 trials? We are in Mpls. Please help us. She is only 55 years old and she is my world.
How about the cancer in my lungs
This is great for those who have cancer
Is it possible to sign up for clinical trials for 2023. I have recurring endometroid carcinoma or serous papillary carcinoma from uterus cancer
By any chance cabn we get this drug in Singapore
My mother has been battling ovarian cancer for seven years. Any chance she could be part of your test group.