Research Confirms Benefit of Supplements for Slowing Vision Loss From AMD

After 10 years, AREDS2 formula shows increased efficacy compared to the original formula, benefit of eliminating beta-carotene.

Age-related macular degeneration (AMD) is an eye disease that can blur your central vision. It is quite common in the U.S., especially among older, white Americans, making it the leading cause of vision loss in the U.S. In addition to regular physical activity, quitting smoking, and maintaining healthy blood pressure and cholesterol levels, supplements can help reduce your risk for AMD or slow its progression.

The Age-Related Eye Disease Studies (AREDS and AREDS2) established that dietary supplements can slow the progression of age-related macular degeneration (AMD), the most common cause of blindness in older Americans. In a new report, scientists analyzed 10 years of AREDS2 data. They show that the AREDS2 formula, which substituted antioxidants lutein and zeaxanthin for beta-carotene, not only reduces the risk of lung cancer due to beta-carotene, but is also more effective at reducing the risk of AMD progression, compared to the original formula. A report on the study, funded by the National Institutes of Health was published in the journal JAMA Ophthalmology on June 2, 2022.

Age-related macular degeneration (AMD) is an eye disease that can blur your central vision. It happens when aging causes damage to the macula — the part of the eye that controls sharp, straight-ahead vision. The macula is part of the retina (the light-sensitive tissue at the back of the eye). AMD is a common condition — it’s a leading cause of vision loss for older adults.

“Because beta-carotene increased the risk of lung cancer for current smokers in two NIH-supported studies, our goal with AREDS2 was to create an equally effective supplement formula that could be used by anyone, whether or not they smoke,” said Emily Chew, M.D., director of the Division of Epidemiology and Clinical Application at the National Eye Institute (NEI), and lead author of the study report. “This 10-year data confirms that not only is the new formula safer, it’s actually better at slowing AMD progression.”

AMD is a degenerative disease of the retina, the light-sensitive tissue at the back of the eye. Progressive death of retinal cells in the macula, the part of the retina that provides clear central vision, eventually leads to blindness. Treatment can slow or reverse vision loss; however, no cure for AMD exists.

The original AREDS study, launched in 1996, showed that a dietary supplement formulation (500 mg vitamin C, 400 international units vitamin E, 2 mg copper, 80 mg zinc, and 15 mg beta-carotene) could significantly slow the progression of AMD from moderate to late disease. However, two concurrent studies also revealed that people who smoked and took beta-carotene had a significantly higher risk of lung cancer than expected.

National Eye Institute’s Dr. Emily Chew performs an eye exam. Credit: NEI

In AREDS2, begun in 2006, Chew and colleagues compared the beta-carotene formulation to one with 10 mg lutein and 2 mg zeaxanthin instead. Like beta-carotene, lutein and zeaxanthin are antioxidants with activity in the retina. The beta-carotene-containing formation was only given to participants who had never smoked or who had quit smoking.

AMD develops slowly in some people and quickly in others. If you have early AMD, you may not notice vision loss for a long time. That is why it is critical to get frequent eye exams to determine if you have AMD.

At the end of the five-year AREDS2 study period, the researchers concluded that lutein and zeaxanthin did not increase the risk for lung cancer, and that the new formation could reduce the risk of AMD progression by about 26%. After the completion of the five-year study period, the study participants were all offered the final AREDS2 formation that included lutein and zeaxanthin instead of beta-carotene.

In this new report, the researchers followed up with 3,883 of the original 4,203 AREDS2 participants an additional five years from the end of the AREDS2 study in 2011, collecting information on whether their AMD had progressed to late disease, and whether they had been diagnosed with lung cancer. Even though all the participants had switched to the formula containing lutein and zeaxanthin after the end of the study period, the follow-up study continued to show that beta-carotene increased risk of lung cancer for people who had ever smoked by nearly double. There was no increased risk for lung cancer in those receiving lutein/zeaxanthin. In addition, after 10 years, the group originally assigned to receive lutein/zeaxanthin had an additional 20% reduced risk of progression to late AMD compared to those originally assigned to receive beta-carotene.

“These results confirmed that switching our formula from beta-carotene to lutein and zeaxanthin was the right choice,” said Chew.

Reference: “Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report #28” by Emily Y. Chew, MD; Traci E. Clemons, PhD; Elvira Agrón, MA; Amitha Domalpally, MD, PhD; Tiarnán D. L. Keenan, BM, BCh, PhD; Susan Vitale, PhD; Claire Weber, MSc; Douglas C. Smith, BS and William Christen, ScD; for the AREDS2 Research Group, 2 June 2022, JAMA Ophthalmology.
DOI: 10.1001/jamaophthalmol.2022.1640

The study was funded by the NEI Intramural program (EY000546) and through contracts (AREDS2 contract HHS-N-260-2005-00007-C; ADB contract NO1-EY-5-0007; AREDS Contract NOI-EY-0-2127, and contract HHS-N-263-2013-00005-C). The AREDS2 contracts were supported by the NIH Office of Dietary Office of Dietary Supplements, the National Center for Complementary and Integrative Health, the National Institute on Aging, the National Heart, Lung, and Blood Institute, and the National Institute of Neurological Disorders and Stroke. The study took place at the NIH Clinical Center.

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  • Charles G. Shaver

    As a senior lay American male victim, investigator and discoverer previously suffering a mild stroke and diagnosed with both minor AMD and cataracts, who’s been increasingly battling chronic subclinical non-IgE-antibody-mediated food and food additive allergies (not yet recognized as such by mainstream medicine) aggravated with US FDA approved food poisoning (primarily added ‘cultured’ MSG since 1980 and modified soy protein since the early 1970s; others) for forty-one years and counting, not only can I agree with the professional findings in the article but I can explain some of them. As I posted earlier in more detail at the link at the bottom, Dr. Arthur F. Coca’s (my) kind of allergies cause systemic inflammation (as opposed to mere intolerance and digestive/intestinal problems) which can create acidic blood and wreak havoc on all of an afflicted person’s hormonal, metabolic and nutritional systems.

    To make matters worse, once the blood becomes acidic (e.g. a calcium deficiency not indicated-for with standard blood testing) with the blood vessels in the eyes being the most dense in the body, it stands to reason a serious problem would present there first, AMD and/or cataracts. Sad to say, based on my now decades of at-home experience, ‘allergies rule!’ Antioxidant supplements may help to slow the progression of various chronic and degenerative diseases but probably never cure them. As Dr. Coca informed us long ago, it is possible to identify one’s particular allergic offenders on one’s own, at-home. More immediately, though, it might be sufficient to simply completely avoid commercially prepared pseudo-foods illegally adulterated, contaminated and permeated with FDA approved food poisoning. More, among my writings.

    https://scitechdaily.com/obesity-might-be-a-result-of-your-bodys-chemistry/#comment-685611

  • John

    Wow, that one guy has a long comment. Glad there is a good supplement to take. I wish they studied how it works for very early AMD patients. Doctors don’t recommend the supplements until you are down the road on AMD which seems stupid. I started AREDS 2 as soon as I was diagnosed even though they said it may never progress or be years away as I only had a “smidgen” of AMD.

    • Charles G. Shaver

      Is a serious issue and I try to provide sufficient information for people to begin to help themselves.

  • lisa nagy md

    i too promote and practice environmental medicine a la Coca rinkle randolph rea and rapp. lisa nagy md

    • Charles G. Shaver

      Thanks for the input. Not a doctor/practitioner, much more than just Coca. I think food sensitivities may be the root cause; how’s your uric acid level? More from me soon through your website.

  • Jonnie Sacramento

    I was diagnosed with early AMD at 62. I quit smoking cigarettes and utilize the Mediterranean and MIND lifestyle eating diet. I also started taking Areds2 and had to stop taking it for five days for a colonoscopy. I started seeing the effects of not taking it. Since then I take it religiously and have had no progression of AMD. I’m a believer in the supplement!

  • John

    That’s cool and all, but why is the cover image Baby Yoda’s cradle?

  • Khamruddin

    Could kindly please our expression is habit of Mohammad swallaliswalam habit and like barliee, hooney, panioor… Diat reguller. Resulate 100./.

  • Amber Mignault

    EXTREAM CAUTION!!!!!
    Dr prescribed this medication to my mom. After years of taking, my mom started developing neuropathy in her feet, vit b12 Def. And many other symptoms I can’t recall. But u can look up later after I explain.
    She ended up in the hospital for several weeks. Come to find out, she had 3% copper in her body. You are supposed to have at least 85%. The couldn’t figure out why. I did research and discovered the eye meds have so much zink, it over road the copper absorbsortion. So for many years of no copper, it almost killed her. You see, copper and zink figh over absorption. And with the high level of zink it was stopping any copper from getting into the body. If you were to look up copper defencity, all the symptoms over the years, fits everything. All of my moms dr.s all said very interesting. Well they took mom off the mess. She can’t walk and the damage is irreversible. Bad neuropathy in hands and waist down.
    So if you are taking this meds, please consider taking extra copper. You can die from no copper in your system.
    There were so many side affects from this med. From the copper defencity. It affects from your hair down to your toes. Do your research. I did and I saved my mom’s life!!@

    • Charles G. Shaver

      Hello Amber. Thank you for the heads-up on copper. Despite my personal precautions of generally taking only recommended doses of nutritional supplements it appears I, too, may now be suffering from an undiagnosed copper deficiency. Major contributors to the difficulty of being quickly accurately diagnosed with a particular condition and receiving immediately effective treatments may be the presence of undiagnosed chronic subclinical allergy reactions aggravated (or not) with toxic FDA approved food additives, as I mention in my original comment. A high serum level of uric acid may be the primary indicator; chronic hyperuricemia myself since 1981. Preliminary investigation into my own possible copper problem led me to the article at the link below. I wonder if anything in that article might still be helpful for your mother’s condition?

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637704/