Anthocyanins, especially acylated ones in purple vegetables, can reduce type 2 diabetes risk by improving gut health, metabolism, and inflammation control.
According to a recent review article that analyzed the research results on the topic, the risk of type 2 diabetes can be reduced through the consumption of anthocyanins, the red, purple, and blue pigments found in fruits, vegetables, and tubers. These pigments have a positive impact on energy metabolism, gut microbiota, and inflammation. The article also discovered that the beneficial effect of anthocyanins on diabetes is amplified when they are acylated, meaning that an acyl group is attached to the sugar moieties of the anthocyanin.
A great amount of acylated anthocyanins can be found in purple potatoes, purple sweet potatoes, radishes, purple carrots, and red cabbages, whereas bilberries and mulberries contain mostly nonacylated anthocyanins. Acylated anthocyanins are poorly absorbed in digestion, but they have probiotic properties and reduce the risk of diabetes more efficiently than nonacylated anthocyanins.
“The studies have shown that, in addition to changing physical and chemical properties, the acylation affects how the anthocyanins are absorbed and metabolized,” says Postdoctoral Researcher Kang Chen at Food Sciences Unit, University of Turku, Finland.
Benefits of Acylated Anthocyanins on Gut Health
The acylated anthocyanins are more effective antioxidants than the nonacylated anthocyanins, and they can also improve the intestinal barrier that enables the absorption of necessary nutrients. Furthermore, the acylated anthocyanins maintain gut microbiota homeostasis, suppress pro-inflammatory pathways, and modulate glucose and lipid metabolisms.
“The plant’s genotype defines what kind of anthocyanins they produce. In general, purple vegetables contain many acylated anthocyanins. Also, purple potatoes, especially the Finnish variety called ‘Synkeä Sakari’, is abundant in acylated anthocyanins,” says Chen.
Acylated anthocyanins travel through our bodies from the upper gastrointestinal tract to the colon where they are metabolized by the gut microbiota. Glucose transporters are involved in anthocyanin absorption, but different glucose transporters are responsible for the absorption of acylated and nonacylated anthocyanins. The acylated and nonacylated anthocyanins also have different impacts on the enzymes involved in metabolism.
“The latest research has shown that the acylated and nonacylated anthocyanins can impact type 2 diabetes in different ways,” Chen summarizes.
Reference: “Anthocyanins as Promising Molecules Affecting Energy Homeostasis, Inflammation, and Gut Microbiota in Type 2 Diabetes with Special Reference to Impact of Acylation” by Kang Chen, Maaria Katariina Kortesniemi, Kaisa Marjut Linderborg and Baoru Yang, 14 December 2022, Journal of Agricultural and Food Chemistry.
DOI: 10.1021/acs.jafc.2c05879
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