Immunotherapy is a form of medical treatment that enhances the body’s natural immune system to fight diseases, most notably cancer. It represents a significant shift from traditional treatments like chemotherapy and radiation, as it often leads to fewer side effects and can be more precisely targeted. There are several types of immunotherapies, including checkpoint inhibitors that help the immune system recognize and attack cancer cells, cancer vaccines that trigger the immune system to act against certain cancer-related antigens, and adoptive cell therapies where immune cells are taken from the patient, engineered to be more effective, and reintroduced into the body. This treatment is also being explored for its potential against autoimmune diseases, allergies, and infectious diseases like HIV. The success of immunotherapy has transformed oncology, offering hope for durable responses and even remissions in situations where other treatments have failed.
A study revealed that tumors block immune responses by using prostaglandin E2, providing new insights for enhancing cancer immunotherapies. Tumors actively inhibit the development of…
The use of poly-ICLC in combination with a dendritic cell-based immunotherapy vaccine shows promise as a treatment for patients with deadly brain cancer. Researchers at…
Researchers from the University of Houston identified CD8-fit T cells with high motility and serial killing abilities, potentially enhancing T-cell cancer therapies. The study used…
A new immunotherapy developed at UCL using engineered immune cells has shown promising preclinical results against a bone cancer called osteosarcoma, as part of a…
Researchers at Trinity College Dublin have achieved a significant breakthrough that could lead to the development of innovative immune therapies for cancer. They found that…
The final work of a late scientist from the University of Virginia School of Medicine has paved the way for life-saving new treatments for solid…
FOXO1 is required for T cell memory and is linked to longer-lasting clinical outcomes in CAR T cell therapy. CAR T cell therapy has transformed…
A new study conducted by the University of British Columbia reveals a safe path to overcoming food allergies for older children and others who can’t…
By leveraging mutations from cancerous cells, researchers have engineered T cells that are over 100 times more potent against cancer, promising a new era in…
Researchers have engineered T cells with a cancer-derived mutation, boosting their potency against tumors over 100-fold without toxicity, marking a significant advancement in immunotherapy that…
A groundbreaking study shows that mitochondrial DNA mutations are key indicators of a patient’s likelihood to respond to immunotherapy, revolutionizing cancer treatment approaches. Cancer Research…
A study reveals that blocking the PD-L2 protein in senescent cancer cells post-chemotherapy boosts the immune system’s ability to destroy these cells, potentially enhancing chemotherapy’s…
Research shows B4GALT3 deficiency in mice slows tumor growth and alters immune responses, suggesting new cancer treatment strategies. An old campaign slogan for cough syrup,…
Recent findings at Cold Spring Harbor Laboratory (CSHL) shine a new light on pancreatic cancer. Cold Spring Harbor Laboratory researchers have uncovered that pancreatic cancer…
A More Effective Experimental Design for Engineering a Cell Into a New State MIT and Harvard researchers have developed a novel computational technique that can…
The small molecule, now in clinical trials, increases activity of immune cells and sensitivity of tumors to immune attack. Cancer immunotherapy drugs called PD-1 inhibitors…
Researchers in Western Switzerland have uncovered how to enhance the tumor-fighting abilities of CAR-T cells, artificial immune “super-cells” utilized in battling blood cancers. Among available…
The findings could help doctors identify cancer patients who would benefit the most from drugs called checkpoint blockade inhibitors. Cancer drugs known as checkpoint blockade…