Yale Cardiologists Identify a Potential Therapeutic Target for Pulmonary Hypertension

Cardiologists Identify Potential Therapeutic Target for Pulmonary Hypertension

Progenitor smooth muscle cells are located at the muscular border in normal lung blood vessels.

In a newly published study, Yale scientists detail the discovery of a novel cell type that is essential to the development of pulmonary hypertension and promises to lead to improved therapies.

Cardiovascular diseases are the leading cause of death worldwide. As a prime example, pulmonary hypertension is especially lethal, with one-half of patients dying within three years of being diagnosed. New research aims to change that by finding a therapeutic target for pulmonary hypertension.

Pulmonary hypertension is a form of high blood pressure that affects arteries in the lungs. The molecular and cellular events leading to the development of the disease are not well understood. To gain further insight, scientists in the Yale Cardiovascular Research Center studied human lung samples and a mouse model of this devastating disease.

A Potential Therapeutic Target for Pulmonary Hypertension

A single progenitor cell identified in normal lung blood vessels migrates and multiplies in pulmonary hypertension.

The researchers found specialized cells in the smooth muscle of lung blood vessels that proliferate in pulmonary hypertension. “It is remarkable that these progenitor cells are present in the normal lung — almost sitting there poised to multiply and migrate in disease,” said Dr. Daniel M. Greif, senior author and assistant professor of cardiology. They also discovered the molecular signals, including the protein KLF4, that regulate these cells.

Greif and his co-authors plan to further classify the progenitor cells in order to devise novel therapies to benefit patients with pulmonary hypertension. “If a patient is diagnosed early, and these cells could be targeted and manipulated, we could potentially attenuate the course of the patient’s disease,” he said.

The research was published October 7 in Science Translational Medicine.

Publication: Abdul Q. Sheikh, et al., “Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension,” Science Translational Medicine, 07 Oct 2015: Vol. 7, Issue 308, pp. 308ra159; DOI: 10.1126/scitranslmed.aaa9712

Source: Ziba Kashef, Yale University

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