Pharmacology News

FDA-Approved Drug Treats a Rare Cardiac Disease

December 15, 2016

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Cancer Drug Treats Rare Cardiac Disease

New research shows that a low-dose of the FDA-approved drug dasatinib improves heart function in Noonan syndrome. About 1 in 2,500 babies born in the United States each year have Noonan syndrome (NS), a genetic disorder that results in severe heart defects, among other symptoms. A mutation in a gene called PTPN11 which encodes for […]

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New Synthetic Process Provides a Better View of Diabetes, Inflammation, and Human Aging

October 19, 2015

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New Process Provides a Better View of Diabetes, Inflammation, and Human Aging

In a newly published study, scientists describe the new synthesis, as well as a new synthetic methodology, that offers a better glimpse into diabetes and the aging process. A synthetic process developed at Yale University will allow researchers to study a key molecule involved in diabetes, inflammation, and human aging. The new process synthesizes glucosepane, […]

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Pharmaceutical Firms “Underinvest” in Long-Term Cancer Research

July 28, 2015

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Do Firms Underinvest in Long-Term Cancer Research

A newly published study from MIT and the University of Chicago reveals that pharmaceutical firms “underinvest” in long-term research to develop new cancer-fighting drugs due to the greater time and cost required to conduct such research. Specifically, drugs to treat late-stage cancers are less costly to develop than drugs for earlier-stage cancers, partly because the […]

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Diabetes Medication Could Be Used to Reduce Tumor Growth

July 14, 2015

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Diabetes Medicine Could Reduce Tumor Growth

Researchers from UCLA have identified a new mechanism that delivers glucose to cancer cells, providing evidence that drugs used to treat diabetes could be used to reduce tumor growth in pancreatic and prostate cancers. Cancer cells require high amounts of the sugar glucose to survive and grow, and long-standing research has established passive glucose transporters, […]

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A Real-Time Blood Test for Cancer Tumors

February 27, 2015

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A Real-Time Blood Test for Solid Lung Cancer Tumors

A newly published study from Yale University shows that liquid biopsies offer a real-time blood test for solid lung cancer tumors. In the rapidly changing world of molecular profiling for genetic diseases, cancer researchers are increasingly optimistic about the reality of a simple blood test to monitor and treat solid tumor cancers. Recent studies show […]

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Scientists Come Together to Reveal Cancer’s Strategies

November 5, 2014

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Scientists Come Together to Reveal Cancer’s Strategies

In a new study, a group of scientists detail how they fused the power of statistical physics and artificial intelligence into a mathematical toolkit that can turn cancer-mutation data into multidimensional models that show how specific mutations alter the social networks of proteins in cells. While this may sound like the setup to some late-night […]

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Researchers Discover a New Signaling Pathway to Combat Excess Body Weight

October 17, 2014

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Researchers Discover a New Signaling Pathway to Combat Excess Body Weight

An international team of researchers has discovered a new signaling molecule capable of activating brown fat cells. The number of overweight persons is greatly increasing worldwide – and as a result is the risk of suffering a heart attack, stroke, diabetes or Alzheimer’s disease. For this reason, many people dream of an efficient method for […]

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Oceanographers Discover Compound That Shows Potency Against Anthrax

July 18, 2013

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Chemical Compound Discovered at Sea Shows Potency Against Anthrax

Oceanographers from Scripps UC San Diego have discovered a microorganism that produces a chemical compound that may offer new treatments for anthrax and other ailments such as methicillin-resistant Staphylococcus aureus (MRSA). A team led by William Fenical at Scripps Institution of Oceanography at UC San Diego has discovered a new chemical compound from an ocean […]

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Researchers Identify the P2Y2 Receptor Molecule as the Gateway for Metastases

July 3, 2013

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Activated Blood Platelets Enable Cancer Cells to Penetrate Blood Vessels

Researchers from the Max Planck Institute have identified the P2Y2 receptor molecule on the cells of the blood platelet wall as the gateway that enables cancer cells to penetrate blood vessels and to enter the organs. Malignant tumors often spread to remote areas of the body. In the majority of cases, metastases formation develops via […]

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Beer’s Bitter Compounds May Result in New Treatments for Diabetes and Other Maladies

January 30, 2013

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Humulone Molecule

Using a process called X-ray crystallography, scientists at the University of Washington have determined the precise configuration of humulones, which may result in new pharmaceuticals to treat diabetes, some types of cancer and other maladies. Researchers employing a century-old observational technique have determined the precise configuration of humulones, substances derived from hops that give beer […]

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Study Shows That TRPA1 is Essential in the Skin’s Response to UVA Light

January 23, 2013

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The Skins Response to UVA Light

Researchers at Brown University discovered that human melaoncyte skin cells rely on an ion channel called TRPA1 to allow a flood of calcium ions, which signal the cell to begin making melanin, into the cells when they are exposed to UVA light. Providence, Rhode Island – Brown University – Last year, a team of researchers […]

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3D Printing Using DNA Could Make Drugs

January 2, 2013

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Credit: widdowquinn/Flickr)

New technology that combines the computer-aided design software inSequio with nanoscale fabrication technology could allow for the 3D printing of drugs using DNA. The Parabon Essemblix Drug Development Platform allows for the rapid, and precise, specific placement of every atom in a compound it designs. The scientists used the inSequio software to design molecular pieces […]

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Scorpion Protein Helps Illuminate Brain Tumors

December 18, 2012

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scorpion-venom-tumor

In order to help surgeons come up with a way to distinguish brain tumors from healthy tissue, scientists are trying to use a scorpion protein. Jim Olson, pediatric neuro-oncologist at Seattle Children’s Hospital, came across a report that described a scorpion toxin that binds to brain tumors, but not to healthy cells. By linking a […]

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Diuretic Drug Could Help Treat Autism

December 11, 2012

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child-with-autism

The drug bumetanide, which has been used for decades to treat high blood pressure and other conditions, has now shown some promise in a small clinical trial for autism spectrum disorder. The drug reduced the overall severity of behavioral symptoms after 3 months of daily treatment. The scientists published their findings in the journal Translational […]

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Radiation Exposure Could Be Countered By Ingesting Ex-Rad Pills

December 11, 2012

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nuclear-bomb

The US Department of Defense has been developing pills that will protect humans from radiation. The pills are named Ex-Rad and were developed by Onconova Therapeutics in conjunction with the DoD. The scientists published their findings in the journal Radiation Research. Once humans have been exposed to radiation, there hasn’t been much they could do […]

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Crystal Meth Could Reduce Susceptibility to the Common Flu

November 21, 2012

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methamphetamine-flu

Researchers suggest that a small dose of methamphetamine, i.e. crystal meth, could reduce the replication of the human influenza virus. The scientists published their findings in the journal PLoS ONE. Scientists from the National Health Research Institutes in Taiwan and the University of Regensburg in Germany have been working together to see how methamphetamine interacts […]

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MDMA Provides Prolonged Relief from Severe Stress

November 21, 2012

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ecstacy-pills

A new study indicates that the benefits of MDMA-assisted psychotherapy for patients with post-traumatic stress disorder (PTSD) persist years after the first treatment of the drug. The scientists published their findings in the Journal of Psychopharmacology. This could help patients with PTSD who do not respond to traditional treatments. However, the results come from a […]

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Dutch Company Will Start Selling Gene Therapy Treatment in 2013

November 6, 2012

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gene-therapy

A Dutch company, uniQure, states that it will start selling the first human gene therapy to be approved in the West by mid-2013. They expect an explosion of similar therapies to be available soon. Glybera was approved by the European Commission on October 25. This drug treats the extremely rare disorder lipoprotein lipase deficiency (LPLD) […]

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