Yale University News

Lysosomes May Contribute to Alzheimer’s Disease

June 30, 2015

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Lysosomes May Contribute to Alzheimer's

New research from Yale University shows lysosomes, the “garbage disposal” systems of cells, can fail and perhaps contribute to Alzheimer’s disease. Lysosomes, the “garbage disposal” systems of cells, are found in great abundance near the amyloid plaques in the brain that are a hallmark of Alzheimer’s disease. Scientists have long assumed that their presence was […]

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Overuse of Medical Services Increases Healthcare Costs

June 29, 2015

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Is Healthcare Taking Advantage of You

Are doctors running the bill up on you? A new study from Yale University shows that a key factor to increased healthcare costs is overuse of medical services. As the cost of health care in the United States continues to rise, a new study by Yale researchers offers insight into a key factor influencing increased […]

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Study Shows Muscle Contraction May Contribute to Stroke Damage

June 29, 2015

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New Research Shows Muscle Contraction May Contribute to Stroke Damage

The precise regulation of cerebral blood flow is critical for normal brain function, and its disruption underlies many neuropathologies. Using optical imaging, researchers from Yale University found that capillary pericytes in mice and humans do not express smooth muscle actin and are morphologically and functionally distinct from adjacent precapillary smooth muscle cells (SMCs). An investigation […]

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Study Shows Arthritis Drug Restores Skin Color for Vitiligo Patients

June 26, 2015

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Arthritis Drug Restores Skin Color in Vitiligo Patients

New research from Yale University demonstrates the effectiveness of tofacitinib for treating vitiligo. After five months of treatment, the white spots on the patients face and hands were nearly gone and tofacitinib caused no adverse side effects during the course of treatment. shows that Within two months of treatment, the patient experienced partial repigmentation on […]

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Researchers Show How Mechanical Forces Affect Cell Function

June 16, 2015

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Researchers Show Mechanical Forces Role in Cell Function

New research from Yale University reveals how mechanical forces play an integral part in cell function. Nuclear membranes protect genes — life’s most precious cargo — but little is known about why they function in different tissue types. For instance, nuclei in brain cells tend to be soft and pliable while those in bone cells […]

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Scientists Discover Evidence of Methane in Martian Meteorites

June 16, 2015

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Scientists Discover Methane in Mars Meteorites

A newly published study details the discovery of methane in Martian meteorites, a possible clue in the search for life on the Red Planet. The researchers examined samples from six meteorites of volcanic rock that originated on Mars. The meteorites contain gases in the same proportion and with the same isotopic composition as the Martian […]

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New Model Helps Explain the Softness in Earth’s Lithosphere

June 15, 2015

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Understanding the Softness in Earth’s Lithosphere

A new model from researchers at Yale University helps explain the drop in elastic stiffness in the middle of the Earth’s continental lithosphere. Lithosphere is the stiff layer of rock that lies atop the slow-motion convection of Earth’s solid, yet ductile, interior. It is the “plate” of plate tectonics, the system of interlocking fragments that […]

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Pupil Diameter Linked to Task Performance

June 15, 2015

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Pupil Diameter Predicts Task Performance

Researchers from the Yale School of Medicine reveal how changes in the activity of individual neurons during performance of a task correspond exactly to the diameter of the pupil, showing signatures of high arousal for a wide diameter and low arousal for a small diameter. If you want to know who is ready to perform […]

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PROTACs: A New Type of Drug That Can Target All Disease-Causing Proteins

June 11, 2015

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New Type of Drug Can Target All Disease-Causing Proteins

A newly published study from Yale University details the discovery of a new type of drug, called Proteolysis Targeting Chimeras (PROTACs), which can target all disease-causing proteins. Current drugs block the actions of only about a quarter of known disease-causing proteins, but Yale University researchers have developed a technology capable of not just inhibiting, but […]

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Study Projects How Climate Change Will Affect the Functions Birds in Ecosystems Worldwide

June 10, 2015

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Climate Change Will Affect the Functions Performed by Birds

New research from Yale University projects how climate change will affect the functions performed by birds in ecosystems worldwide. As changing climate reshapes the geographic range of thousands of bird species in the coming decades, ecosystems across wide swaths of the planet may be compromised, a new study warns. Based on environmental projections for the […]

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Cavity Shaving Reduces the Risk of a Second Mastectomy

June 1, 2015

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Cavity Shaving Reduces Risk of Double Mastectomy

A newly published study reveals that cavity shaving halved the rates of positive margins and reexcision among patients with partial mastectomy. Removing more tissue during a partial mastectomy could spare thousands of breast cancer patients a second surgery, according to a Yale Cancer Center study. The findings were published online May 30 in the New […]

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Key Areas of the Brain Develop Differently in Adolescents with Bipolar Disorder

May 29, 2015

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Brain Development During Adolescence in Bipolar Disorder

A newly published study from Yale University shows that key areas of the brain that help regulate emotions develop differently in adolescents with bipolar disorder. In brain areas that regulate emotions, adolescents with bipolar disorder lose larger-than-anticipated volumes of gray matter, or neurons, and show no increase in white matter connections, which is a hallmark […]

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CCNE1 Gene Turns Back Cellular Clock

May 22, 2015

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Researchers Discover Human-Specific Gene That Turns Back Cellular Clock

Yale researchers have discovered a gene that turns back the cellular clock, greatly aiding the reprogramming of mature cells. An exhaustive analysis of factors that allow mature cells to become like embryonic stem cells again has revealed a spliced form of a gene found only in primates that greatly aids the reprogramming of mature cells. […]

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Yale Researchers Illuminate Major Evolutionary Patterns of Snakes

May 20, 2015

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Researchers Generate a Family Tree for Living and Extinct Snakes

A team of researchers from Yale University analyzed snake genomes, modern snake anatomy, and information from the fossil record, generating a family tree for living and extinct snakes and illuminating major evolutionary patterns that have played out across snake evolutionary history. The ancestral snakes in the grass actually lived in the forest, according to the […]

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Brain Activity Predicts Weight Gain

May 20, 2015

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New Study Shows How the Brain Responds to Food Cues

A new study set to appear in The Journal Neuroscience illustrates that it is the way the brain responds to food cues when individuals are not hungry that predicts weight gain and that the reasons why people gain weight can be fundamentally different. The way the brain responds while sipping a delicious milkshake can predict […]

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Drug-Resistant EGFR May Have “Achilles Heel”

May 19, 2015

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Two Experimental Drugs Show Promise Against Drug-Resistant EGFR

Researchers from Yale University have discovered a key structural difference in the drug-resistant form of EGFR that could lead to new strategies to combat the disease. Drugs introduced more than a decade ago that target mutations in a protein known as the epidermal growth factor receptor (EGFR) held the promise of personalized treatments for a […]

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New Chemical Catalysts Are Less Expensive and More Sustainable

May 18, 2015

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New Chemical Catalysts

Researchers from Yale University have developed a new family of chemical catalysts that are expected to lower the cost and boost the sustainability of the production of chemical compounds used by a number of industries. The new catalysts are based on palladium, a rare and expensive metal. Palladium catalysts are used to form an array […]

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A Promising New Treatment for Multiple Sclerosis

May 15, 2015

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Researchers Solve Multiple Sclerosis Puzzle

New research shows that auto-reactive T cells in MS patients produce different types of inflammatory hormones called cytokines than they do in healthy subjects, opening the door to new treatments for the disease. Evidence has long suggested multiple sclerosis (MS) is an autoimmune disease, but researchers have been puzzled because they found the same T […]

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