Researchers Discover Possible Solutions To Reverse the Impact of Alzheimer’s Disease

Alzheimers Dementia Brain Disease Concept

Researchers at the University of North Carolina at Chapel Hill have introduced an innovative drug delivery system using amyloid fibers that respond to body heat by untwisting, potentially offering a new way to treat neurodegenerative diseases. This system builds on the understanding of how amyloid plaques, associated with Alzheimer’s disease, form and progress, offering hope for reversing their effects.

New findings could be useful in treatment to untwist and degrade amyloid plaques in Alzheimer’s disease.

University of North Carolina at Chapel Hill researchers have developed a new drug delivery platform that harnesses helical amyloid fibers designed to untwist and release drugs in response to body temperatures.

A new research paper published in Nature Communications reveals groundbreaking structural details into how diseases form much like Alzheimer’s disease. With this knowledge, the group may have uncovered a unique mechanism to reverse both the deposits and their impact on those suffering from these conditions.

UNC-Chapel Hill researcher Ronit Freeman is leading a research group with investigators from the Lynn lab at Emory University looked at the core beta amyloid-42 peptide, the key portion driving amyloid plaque assembly and deposits in the brains of patients with Alzheimer’s disease. By creating synthetic variations of the peptide in the lab, they were able to discover how to control the way that these molecules assemble and twist.

Synthetic Peptide Innovation

“The ability of these amyloid materials to be untwisted and degraded highlights potential for treatments modifying and subsequently reversing plaques found in Alzheimer’s and other neurodegenerative diseases,” said Freeman. “We know that the direction of the amyloid fibril twists is associated with different disease progression states. Imagine that by a simple treatment, we could modify amyloids to change their shape and disappear – this is what our discovery might enable us to do in the future.”

Using advanced spectroscopic techniques, the researchers probed how individual peptides interact, revealing information about assembly rates, distances between peptides, peptide alignment, and importantly the direction of twist. High-resolution electron and fluorescent microscopy were used to characterize the morphology of the materials at different temperatures.

The investigators identified that the N-terminal domain of the peptide is important for programming the shape of the assembly such as tubes, ribbons, or fibers, while C-terminal modifications direct either a left- or right-handed twist within the material. Using these design rules, a series of peptides were tuned to switch on-demand between left-handed and right-handed twisted ribbons in response to changing temperatures. This twist inversion then renders the material susceptible to degradation by natural proteins, a desirable feature for materials used as delivery vehicles.

Reference: “Uncovering supramolecular chirality codes for the design of tunable biomaterials” by Stephen J. Klawa, Michelle Lee, Kyle D. Riker, Tengyue Jian, Qunzhao Wang, Yuan Gao, Margaret L. Daly, Shreeya Bhonge, W. Seth Childers, Tolulope O. Omosun, Anil K. Mehta, David G. Lynn and Ronit Freeman, 26 January 2024, Nature Communications.
DOI: 10.1038/s41467-024-45019-2

Be the first to comment on "Researchers Discover Possible Solutions To Reverse the Impact of Alzheimer’s Disease"

Leave a comment

Email address is optional. If provided, your email will not be published or shared.