New research exposes the molecular switches that let some cancers shapeshift and reveals how they…
Browsing: Structural Biology
Structural biology is a subfield of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules like proteins, nucleic acids, and their complexes. It aims to provide a detailed understanding of the molecular architecture of these macromolecules and how alterations in their structures affect their function. Techniques such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryo-electron microscopy (cryo-EM) are commonly used to determine the positions of atoms within a molecule in three-dimensional space. Insights gained from structural biology are crucial for elucidating the mechanisms of biological processes and for designing drugs that can interact with proteins and other targets at the molecular level. This field has contributed significantly to the development of new therapeutics, understanding disease mechanisms, and the design of novel enzymes for industrial applications.
Scientists have uncovered an unexpected function for a crucial protein involved in cell division. Reported…
Scientists have mapped the yellow fever virus in unprecedented detail. Researchers at the University of…
A new drug targets RAS-PI3Kα pathways without harmful side effects. It was developed using high-performance…
Researchers used advanced microscopy to uncover important protein structures. For the first time, two important…
Scientists discovered that ciprofloxacin blocks ACE through a novel mechanism, opening new paths for safer…
Filopodia help cells move but also aid cancer spread. Scientists have revealed how fascin proteins…
PELSA is a sensitive, versatile method for identifying ligand-binding proteins and sites in native systems…
A new study reveals a ‘nano-switch’ in ferredoxin that affects its electron transfer, which could…
Scientists from EMBL Hamburg and CSSB have uncovered the molecular mechanisms behind how the body…
Neocapritermes taracua termites carry a life-ending enzyme that, when mixed with another compound during attacks,…
Exploring geometry and chirality in life by probing the sphinx tile. Why is the heart…
Scientists at Scripps Research have developed atomic-level structural models of enzymes linked to autoimmune and…
A recent re-emergence and outbreak of Mpox brought poxviruses back as a public health threat,…
A significant study identifies a genetic variant in the SYCE2 gene that heightens the risk…
New crystallography experiments using high pressure and heat to reveal how proteins change shape could…
Neurons communicate through chemical signals known as neurotransmitters. Researchers at St. Jude Children’s Research Hospital,…
University of Missouri researchers’ conceptual design of a nanomaterial could potentially pave the way for…