Warning: Using Common Painkillers Alongside Birth Control Pills Increases Your Risk of Blood Clots

Contraceptive Birth Control Pills

New research finds an elevated risk of blood clots in women using NSAIDs with hormonal contraception, particularly high-risk types and diclofenac. The research calls for greater awareness and careful consideration of safer pain relief and contraceptive options.

Researchers advise that while the absolute risk remains low, women should be informed accordingly.

People using non-steroidal anti-inflammatory painkillers in combination with hormonal contraceptives may face a slightly higher risk of venous thromboembolism (VTE), according to a comprehensive Danish study recently published in The BMJ.

The risk was greater in women using combined oral contraceptives containing third or fourth-generation progestins, but smaller in women using progestin-only tablets, implants, and coils, alongside the non-steroidal anti-inflammatory drugs (NSAIDs) ibuprofen, diclofenac, and naproxen.

The researchers stress that the absolute risk of developing a serious blood clot is low, even in women using high-risk hormonal contraception. But given the widespread use of both hormonal contraception and NSAIDs, they say women should be advised of this potential drug interaction accordingly. 

Classification of Hormonal Contraception and NSAID Use

NSAIDs have previously been linked to blood clots, but little is known about whether using NSAIDs influences the risk of venous thromboembolism in otherwise healthy women using hormonal contraception.

To address this, researchers used national medical records to track first-time diagnoses of venous thromboembolism among 2 million women aged 15 to 49 years living in Denmark between 1996 and 2017 with no history of blood clots, cancer, hysterectomy, or fertility treatment.

Hormonal contraception was divided into high, medium, and low risk, according to their association with VTE based on previous studies.

High-risk hormonal contraception included combined estrogen and progestin patches, vaginal rings, and pills containing either 50 mcg estrogen or third or fourth-generation progestins. Medium-risk contraception included all other combined oral contraceptives and the medroxyprogesterone injection, while progestin-only tablets, implants, and hormone intrauterine devices (coils) were classed as low or no risk.

A range of potentially influential factors such as age, education level, pregnancy history, prior surgery, high blood pressure, and diabetes, were also taken into account.

In the study, NSAIDs were used by 529,704 women while using hormonal contraception. Ibuprofen was the most frequently used NSAID (60%), followed by diclofenac (20%) and naproxen (6%).

Over an average 10-year monitoring period, 8,710 venous thromboembolic events occurred (2,715 pulmonary embolisms and 5,995 deep venous thromboses), and 228 (2.6%) women died within 30 days of their diagnosis.

Implications and Recommendations

In absolute terms, NSAID use was associated with four extra venous thromboembolic events per week per 100,000 women not using hormonal contraception, 11 extra events in women using medium-risk hormonal contraception, and 23 extra events in women using high-risk hormonal contraception.

Among individual NSAIDs, the association was strongest for diclofenac compared with ibuprofen and naproxen.

This is an observational study, so can’t establish cause, and the researchers highlight several limitations, such as missing information about smoking and obesity, which they say may have affected their results.

Nevertheless, this was a large study based on high-quality registry data and the researchers were able to adjust for a wide range of potentially influential factors. What’s more, the associations persisted after further analysis, suggesting that they are robust.

As such, the researchers conclude: “Using high quality, linkable, national registries, this nationwide study adds new knowledge on the risk of a potentially fatal event during concomitant use of two drug classes often prescribed to otherwise healthy women.”  

They add: “Women needing both hormonal contraception and regular use of NSAIDs should be advised accordingly.”

These data raise important concerns about using NSAIDs, particularly diclofenac, and high-risk hormonal contraception concomitantly, writes Morten Schmidt at Aarhus University Hospital, in a linked editorial.

He suggests that healthcare authorities and regulators should include these findings in their safety assessment of available over-the-counter diclofenac, and women using hormonal contraception and their clinicians should consider alternatives to NSAIDs for analgesia. 

“If treatment with NSAIDs is needed, agents other than diclofenac seem preferable, along with lower-risk hormonal contraceptives such as progestin-only tablets, implants, or intrauterine devices,” he concludes.

The study was funded by the Danish Heart Foundation. 

1 Comment on "Warning: Using Common Painkillers Alongside Birth Control Pills Increases Your Risk of Blood Clots"

  1. dr mehrdad kesiri | December 8, 2023 at 10:51 am | Reply

    Constitution from the language of the gods of the earth and the nature of God Chapter 1 Introduction Part of the author’s life Perhaps I am the first person in Iran to talk about the nature of the gods of the earth In the past few decades, I askedthe clerics about the structure and nature of God himself, and they said, God himself God is not a visible Lord, and He has not appeared to anyone, and no one can see Him, and no God has spoken directly to His prophets.At that time, I was seventeen years old, and I had studied books on horoscopes, galaxies, the stars of the sky, and the planets of the solar system, and the book of physics.I had read Astronomy and the Structure of the Atom written by Albert Einstein.Those books were the first books I had read 42 years ago.When someone has information about astronomy and general information, his mind opens up about knowing the world around him and religious and religious issues.After I had completely read the book that I mentioned, I was arguing with my elder brother who was religious and I said that there is no such thing as God.He may have created the stars.We breathed on you from our own soul that you knew about the secrets of the unseen world and its science, so I said, therefore, it is the soul itself, and the soul burns at millions of temperatures, etc. It is possible that itcould have created the sun itself.God is neither a soul nor a body, I said, so what is the nature of God, in all holy books, God has always used the word us and the plural verb, not the singular verb, which is I, so that God isnot one, how can we accept the words of Islamic clerics, mullahs, They say that God is one and has no partners, isn’t our word a plural verb?I asked most of the clerics this question, but they couldn’t give me a convincing answer.We Iranians have a proverb, they say that the seeker is the finder.The meaning of the finder is that a person thinks about the things a lot.The revelation reveals and manifests to him.In the same way, I realized the nature of the Gods when I saw the souls of the great prophets of my people, Muhammad, the Messenger of God, Zoroaster, Forohar, and Jesus Christ, in a curtain, in that year, the Sassanidyear of the Koresh dynasty, that year.It was 2570, and it was 2010 in the year of Jesus Christ, and it was 1432 in the Arab lunar year.I saw, in four scenes, most of the world’s prophets appeared to me.After 13 years, when they appeared in a white cream curtain, they appeared by the gods of the earth.I understood after 13 years, I understood that the Gods of the earth appeared to me those four prophets, originally they were not themselves, what I mean is that it is not their real soul that all those prophets were gathered in a curtain at the sametime, can it be the soul of those who Their corpses were buried thousands of kilometers away in different places in the world.It is not possible to see the souls of the prophets once in a curtain.I said that we Iranians have a proverb.This example means that whatever a person thinks, his God will reveal the truth to him.I understood that after thirteen years have passed since the time that I explained, four prophets of the Gods of the earth appeared to me.Of course, I must say that they were the prophets of my generation.The last prophet was Jesus Christ.I was him.I agree, but after 13 years of thinking about the scenes of the prophets appearing on that screen, I now understand that it was the Gods of the earth who showed me the images of those beloved prophets.I will talk very, very important about Dr. Najum and Adian Iranzmin Mehrdad

    Constitution from the point of view of God and the nature of the Gods of the Earth Chapter 2 Introduction The continuation of a part of the author’s life and the illegitimacy of the Constitution in the Constitution of the Islamic Republic In this chapter I will talk about theConstitution at the end of the text In the first chapter I said that it had been thirteen years since the souls of the prophets They appeared to me, and I later understood that all the souls of the prophets who lived in different parts of the world,etc., may have gathered to me at the same time.Of course, I understood that the gods of the earth appeared to me.It is difficult for someone who has not seen and experienced the issue that I have raised with his own eyes, to accept this issue.Anyway, when the Gods of the earth choose someone, they reveal their messengers to that person.I know for a hundred hundred that the Gods chose me.Those gods whose structure was developed by humans a hundred million years ago, we call that structure Parvardegar.And I put the structure of Gods.I am connected with the Lord of the Earth through a spirit that has no name.He said that you are the owner of time and you must appear.What does it mean to appear?Appearing means publishing the truths and orders of God, which must be implemented.The orders belong to a nation and a nation that has encountered problems, a nation, oppression, and crimes have been committed in a tyrannical government or a tyrannical government, then the gods of the earth who always have a choice at the promised time, thatis, when God recognizes that crimes have been committed by a particular A religious government then God will bring forth their main chosen people to administer justice, of course, this is because the religious extremists created a problem for the emergence of prophets who want to appearand follow the orders of their God, they are severely criticized by clerics.Like the extremist pacifists who are in Iran, they never allow a prophet to appear because they rule in the religion and through the religion of Islam.His chosen ones send down their orders through inspiration and revelation and inform about the future.The representative of God, Qoumi, this duty is assigned to him by himself through the inspiration and revelation of his Gods.Unfortunately, this heavy duty has been assigned to me, but I do not claim that the Imam of the time I am and I don’t like to look for sorrow on earth because the prophet must always carry sorrow in his arms and must fight withreligious government so that the oppressive religious government that was not chosen by God is overthrown or removed from power that was not the true representative of the people like the Shiite Islamists.Iran, who rode on the neck of the people, God will send his chosen ones to destroy and eliminate those who interfered in the work of the gods of the nation and the nation, like the leaders of Iran’s mullahs and mullahs, who are oppressing andcommitting crimes against the nation of Iran, and in all Iran’s state affairs interfered, the Iranian Islamist and Shia clerics, twelve imams, and interfered with the constitution of Iran after the revolution.

    And they put the issue of imamate in the Islamic religion and in the constitution of the Islamic Republic, the issue of imamate means that in the absence of the 12th Imam of the Shia of Iran, one of the followers of Shia Muslims should be the successorof the Imam of the time, he should lead the Shia people and the Muslims of the Islamic religion that After the death of Imam Khomeini, the task is assigned by the Islamic Council to another Iranian Shiite authority, and that person is the successor of theImam of the time, Hazrat Mahdi, who is currently Ayatollah Seyyed Ali Khamenei in Iran and is the leader of the Islamic Republic, but he is considered by the people of Iran.They did not elect and this person is more than eighty-four years old and for more than forty years in the dictatorial government, the religion and religion of the unfortunate people of Iran has been the religion and religion of Iran.Islam has been imposed.The mullahs who are leaders in the Islamic Republic of Iran and the Majlis of Experts chose Ayatollah Seyyed Ali Khamenei, and he is not Iranian, his father was born in Najaf, the issue of Imamate does not exist in the Islamic religion, and no prophetfrom God has sent down such an order.It has not been done by the Gods of the earth, I am the chosen one of the Gods of Iran, the earth, I am not a prophet, nor the Imam of the time, but with dozens of signs in the date of my birthand when I was injured, and in the numbers of the squares and streets where I lived, and other numbers that are used in the counting of the verses.And the surahs that have been revealed to me, if we number the words and sentences of the surahs, we will be connected to time, and we will be connected to events, signs, and events.I am the chosen one of the Gods of Iran and the owner of time.I am an ordinary person like all Iranians, but the Gods of the earth have chosen me to overthrow the Islamic religion that they imposed on the Iranians and through this Islam, the mullahs of the spiritual mullahs want to rule the people of Iran in Iran,with the help of the French government and its allies.The reason is that they supported Imam Khomeini from France to Iran, and the mullahs want to appoint a leader until the absence of Imam Zaman, and it is not known how long they want to rule over the people of Iran through the religion of Islam inthe regime of the Islamic Republic, and they committed crimes against women and men.Man of Iran, the people of Iran were taken hostage by the mullahs of Iran and the situation of the people of Iran is worse since the medieval renaissance, when four hundred years ago the Christian clerics took power in Europe and committed the most heinous crimes tothe people of that time in Europe.Iran does not want this regime of the Islamic Republic, the condition of the people of Iran is worse than in the Middle Ages in Iran, and the western powers dominated the government of Iran in the hands of the clerics, and Britain, America, theSoviet Union, and France supported Imam Khomeini by promoting Iran, and the President of the United States Jimmy Cartel in 1979, the fall of the Shah and the revolution of Iran.Jimmy Cartel helped Imam Khomeini with 150 million dollars.The United States and its allies must remove the dictatorial and criminal regime of the Islamic Republic from Iran.

    And the constitution of Iran must be changed because you made a ridiculous issue about the Imamate, which was included in the principles of the Islamic religion and in the clauses of the Constitution of Iran.Iran can’t do anything, President George Biden, when young men and women were killed and martyred on the streets of Iranian cities due to protests against the mandatory hijab, George Biden said in his speeches, “We know that Iranian teenagers were killed onthe streets because of the mandatory hijab in Iran.”We support the freedom-loving girls and boys of Iran and we defend their rights, and they should continue to demonstrate in the streets of Iranian cities to protest against the compulsory hijab of Dr. Mehrdad, the author and author of the time, I wrotethe religious and ritual book Law of the Gods of Iran and the Earth.I have eight surahs to number their words, we are connected to the time of events and signs in time, and thus I am the owner of time and the true chosen one of the Gods of the earth, and Iran is connected to all the religionsof the earth.Bring it to America, because we Iranians do not have access to most of the political sites due to the blocking of sites by the dictator regime of the Islamic Republic of Iran, the dictator regime of Iran has taken away freedom from us Iranians, thank youadministrators of this constitutional political and religious website of the religion of Islam It is illegitimate, that is, it is not constitutional.I mean that the Islamic Republic cannot be reconciled with Islam in any way, that is, the Republic has nothing in common with the Islamic religion.In the Constitution of Iran, the extreme clerical Islamists of Iran’s Shiites and all the powers of the parliament took their hands.Fallen clerics, and Iran’s Ayatollahs in the House of Leadership and the Assembly of Leadership Experts accept all candidates who are clerics, and if that person is not of the dress and class of a mullah, they disqualify that person, that is, they do notaccept that person who is a candidate for the presidency, he must be elected The presidential candidate is like the American and French parliaments in Iran, but in Iran, a certain class of Islamic clerics are in power.This situation and this calamity and problem were created by the Ayatollah leaders of Iran, but Imam Khomeini opened their hands to them.If France and their allies, who are the superpowers of the world, had not supported Imam Khomeini in Iran, the people of Iran and the Middle East would not have had so much misery and there would have been no war and conflict in the Middle East?!Dr. Mehrdad is a writer, researcher and analyst of political and religious issues

    I would like to say that when I translate a text for you, its composition and spelling will be changed by Google, but you will probably understand the general theme of the text.I can solve this problem, but it will take time.Send an SMS to my phone number through short message so that I can solve the problem.The Islamic Republic of Iran may have blocked my email or the problem may be from somewhere else.I have sent ten emails and none of them work.Anyway, please let me know what you think.and because the dictator regime of the Islamic Republic has blocked and filtered most of the political and religious sites, if you can and you think it is advisable, post some of my comments on religious, political and scientific sites and say that Mehrdad is the authorof political, religious and scientific issues from Iran.Our emissary in Iran does not have access to special scientific, cultural, etc. sites that are prominent in the world and are highly visited.Thanks to you and the managers and officials of countries abroad, Dr. Mehrdad, the author of political, religious, scientific, cultural, and social content.Dear God, I am Iranian at the moment, not the world, but I can help the representatives of the Gods of other countries.From the point of view of belief, the Gods of the Earth are the same superior force.It is possible that they are neither the soul nor the body.I have not yet discovered the exact nature of the Gods of the Earth, although they have performed miracles for me.And their miracle is the appearance of the great souls of the prophets of the world, and they formed the names of some prophets with clouds for me, and they performed other miracles that I will explain to anyone who wants, and more than this, Ido not think it is permissible to explain about some issues in a comment.which is related to the supernatural, but just know that I will never lie in this regard, may God protect you, if you are an honest person, always wait in things and do not rush in anything, especially in judging Time inthe iran tehran 10:20 pm

Leave a comment

Email address is optional. If provided, your email will not be published or shared.