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Biologists Extend Lifespan in Mice by 35 Percent

February 4, 2016

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Researchers Extend Lifespan in Mice by as Much as 35 Percent

A team of biologists from the Mayo Clinic have shown that senescent cells – cells that no longer divide and accumulate with age – negatively impact health and shorten lifespan by as much as 35 percent in normal mice. The results, which appear today in Nature, demonstrate that clearance of senescent cells delays tumor formation, […]

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Life-Extending Hormone FGF21 Also Protects Against the Loss of Immune Function

January 14, 2016

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FGF21 Hormone Protests Against the Loss of Immune Function

New research from Yale University shows that the hormone FGF21, which extends lifespan in mice by 40%, protects against the loss of immune function that comes with age. Published online in the Proceedings of the National Academy of Sciences on January 11, the study’s findings have future implications for improving immune function in the elderly, […]

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New Research Shows Hyperactive Neurons May Trigger Alzheimer’s

January 13, 2016

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Hyperactive neurons may be culprit in Alzheimer’s

New research from Yale University shows that an increase in neuronal activity can spur the creation of plaques and toxic amyloid beta peptides, which are believed to trigger Alzheimer’s disease. A long-term reduction in neuronal activity reduces amyloid plaques associated with Alzheimer’s disease, Yale University researchers have found. The study, using mouse models of Alzheimer’s, […]

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New Study Shows Neanderthals Boosted Our Immune System

January 7, 2016

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New Research Shows Neanderthals Boosted Our Immune System

A new study from the Max Planck Institute reveals that the mixing of archaic human forms played an important role in shaping the immune system of modern humans. When modern humans met Neanderthals in Europe and the two species began interbreeding many thousands of years ago, the exchange left humans with gene variations that have […]

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Scientists Should Focus on Changes in Species to Recognize and Avoid a Mass Extinction

December 17, 2015

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Reserachers Examine Rarity in Mass Extinctions and the Future of Ecosystems

New research from Yale University urges scientists to move their focus from species extinction to species rarity in order to recognize, and avoid, a mass extinction in the modern world. Writing in the journal Nature the week of December 16, Yale’s Pincelli Hull and colleagues from the Smithsonian Institution argue that modern extinction rates may […]

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Bacteria Can Be Spatially Excluded from the Exchange of Amino Acids

December 9, 2015

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Study Shows Bacteria Can Be Spatially Excluded from the Exchange of Amino Acids

New research shows that bacteria, which reciprocally exchange amino acids, stabilize their partnership on two-dimensional surfaces and limit the access of non-cooperating bacteria to the exchanged nutrients. In natural microbial communities, different bacterial species often exchange nutrients by releasing amino acids and vitamins into their growth environment, thus feeding other bacterial cells. Even though the […]

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Yale Study Shows Topical Ruxolitinib Grows Hair

December 9, 2015

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Topical Ruxolitinib Helps Teen Grow Hair

A new study from Yale University reveals that a topical formulation of an oral medication used to treat bone marrow diseases can be used to grow hair. A young woman who had no scalp or eyebrow hair for years now enjoys a full mane after using a novel cream devised by researchers at Yale School […]

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Yale Study Shows Protein IL-18 Contributes to Colitis

December 4, 2015

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Researchers Identify Key Protein That Contributes to Colitis

New research from Yale University identifies that the protein IL-18 plays a key part in the development of the colitis. The cause of Ulcerative Colitis, a debilitating disease of the intestine, is unclear. A Yale-led study has illuminated the role of a protein that plays a key part in the development of the condition. The […]

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Scientists Overcome Key CRISPR-Cas9 Genome Editing Hurdle

December 3, 2015

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Researchers Develop a Highly Specific Genome-Editing Tool

Using structural knowledge of Cas9, scientists have overcome a key CRISPR-Cas9 genome editing hurdle and developed a highly specific genome-editing tool. Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have engineered changes to the revolutionary CRISPR-Cas9 genome editing system that significantly cut down on “off-target” […]

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Study Shows Amateur Contact Sports Increase Risk of Degenerative Disorder

December 2, 2015

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Football Increases Risk of Degenerative Disorder

Past evidence has shown that professional football players are susceptible to a progressive degenerative disease, chronic traumatic encephalopathy (CTE), which is caused by repetitive brain trauma. Now a new study from the Mayo Clinic reveals a significant and surprising amount of CTE in males who had participated in amateur contact sports in their youth. About […]

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Scientists Discover Genes for a Longer, Healthier Life

December 1, 2015

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Researchers Discover Genes for a Longer Healthier Life

A team of scientists has discovered genes that are involved in physical aging. By influencing only one of these genes, the healthy lifespan of laboratory animals is extended – and possibly that of humans, too. Driven by the quest for eternal youth, humankind has spent centuries obsessed with the question of how it is exactly […]

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Neuroscientists Identify New Mechanism That Contributes to Strengthening Synapses

November 18, 2015

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Newly Identified Mechanism Helps Strengthen Links between Neurons

Neuroscientists from MIT have identified a new mechanism that allows the brain to strengthen links between neurons. When the brain forms memories or learns a new task, it encodes the new information by tuning connections between neurons. MIT neuroscientists have discovered a novel mechanism that contributes to the strengthening of these connections, also called synapses. […]

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How Genetic Defects in Myelin Formation Cause White Matter Diseases

November 17, 2015

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Yale Researchers Show How a Mutated Gene Wreaks Havoc on White Matter

New research from Yale University may shed insight into mechanisms to control the course of multiple sclerosis. Their results point to a role for FAM126A in supporting myelination, an important process in development and also following acute exacerbations in multiple sclerosis. An inherited disease of myelin marked by slow, progressive neurological impairment is caused by […]

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New Model Maps the Development of Stem Cells in the Human Body

November 13, 2015

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New Model Analyses of the Development of Stem Cells

Using the telomeres on the chromosomes of blood cells, scientists have designed a mathematical model for mapping the development of populations of haematopoietic stem cells with advancing age. Stem cells ensure the regeneration and maintenance of the body’s tissues. Diseases like cancer can arise if they spiral out of control. In collaboration with doctors from […]

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Neurons Can Be Changed from One Type Into Another from Within the Brain

November 10, 2015

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Researchers Reprogram Neurons

A newly published study from Harvard biologists shows how neurons can be dramatically changed from one type into another from within the brain and how neighboring neurons recognize the reprogrammed cells as different and adapt by changing how they communicate with them. Building on earlier work in which they disproved neurobiology dogma by “reprogramming” neurons […]

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Neuroscientists Observe Signs of Synaptic Plasticity Emerging in a Living Brain

November 3, 2015

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Researchers Observe Signs of Synaptic Plasticity Emerging in a Living Brain

Using measurements of changes in neural activity in neurons of the inferior temporal cortex of mature nonhuman primates as they observed novel and familiar stimuli, neuroscientists have observed signs of synaptic plasticity emerging in a living brain while it accomplishes the feat of beholding and recognizing stimuli. From the first project David Sheinberg took on […]

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Neuroscientists Reveal That the Ventral Pre-Arcuate Holds “Attentional Template”

October 29, 2015

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MIT Neuroscientists Identify Brain Region That Holds Objects in Memory

Neuroscientists from MIT have identified the region of the brain that holds objects in memory until they are spotted. Imagine you are looking for your wallet on a cluttered desk. As you scan the area, you hold in your mind a mental picture of what your wallet looks like. MIT neuroscientists have now identified a […]

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GDF10 Promotes Brain Cells’ Ability to Form New Connections

October 28, 2015

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New Discovery Could Lead to Better Recovery After Stroke

Scientists from UCLA have identified a molecule (GDF10) that signals brain tissue to form new connections after a stroke. The finding could eventually lead to a new treatment to promote brain repair and functional recovery in people who have suffered a stroke, which is the leading cause of serious long-term disability in adults. The five-year […]

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