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Yale Scientists Track the Development of the Embryo

January 2, 2017

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Researchers Track the Development of the Embryo

Scientists at Yale University have discovered a way to track the precise bits of RNA that control the development of the embryo into trillions of specialized cells in a living animal. The new assay, tested on the genome of zebra fish, allows scientists to pinpoint function of myriad of signals activated after fertilization. “The problem […]

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Yale Study Shows Risk Avoidance in Older Adults is Related to Brain Anatomy, Not Age

December 13, 2016

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Neuroanatomy Accounts for Age-Related Changes in Risk

New research from Yale University and NYU reveals that older adults are less inclined to take risks due to changes in brain anatomy rather than age. The finding adds to scientific understanding of decision making and may lead to strategies for modifying changes in risk behavior as people age. Research has demonstrated that older adults […]

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Common Mechanism May Be Responsible for the Spread of Alzheimer’s and CTE

December 8, 2016

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Alzheimer’s and CTE May Spread Via a Common Mechanism

A newly published study from UC San Francisco reveals that a shared biological mechanism may drive the progression of both Alzheimer’s disease and chronic traumatic encephalopathy. Both Alzheimer’s and CTE are classified as “tauopathies,” a category of diseases characterized by the improper folding and clumping together of a protein called tau (rhymes with “how”) inside […]

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‘NoBody’ – A Microprotein on a Mission

December 5, 2016

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NoBody, A Microprotein on a Mission

Using a technique that has revealed more than 400 new proteins too tiny to be found by other means, scientists from Yale University have helped identify a novel, functional “microprotein” encoded in the human genome. One of those microproteins, called NoBody, is a molecular workhorse involved in sweeping out unneeded genetic material inside cells. Its […]

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New Yale Study Points to a Possible Treatment for a Rare Vascular Disease

November 29, 2016

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Study Reveals a Possible Treatment for a Rare Vascular Disease

New research from Yale University points to a possible treatment for a rare genetic disorder that affects blood vessels. In individuals with a rare genetic disorder that affects blood vessels, arteries and veins develop abnormal connections, causing bleeding in the skin, nose, and other organs. In most cases, the condition — hereditary hemorraghic telangiectasia, or […]

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Inhibiting the AIM2 Pathway Could Potentially Limit Radiation Damage to Cells

November 11, 2016

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Study Pinpoints Protein That Detects Damage from Radiation

New research from Yale University shows that a drug that blocks or inhibits the AIM2 pathway could potentially limit the deleterious side effect of chemotherapy or radiotherapy on cancer patients. High doses of radiation from cancer treatment can cause severe damage to cells and tissues, resulting in injury to bone marrow and the gastrointestinal tract. […]

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Study Shows A Widespread Disruption of Brain Activity During Absence Seizures

November 8, 2016

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Disruptions of Brain Activity in Absence Seizures

New research from Yale University shows that the entire brain is disrupted for 10 seconds or more at a time in absence seizures. Scientists believed that absence seizures — the brief loss of consciousness often mistaken for day-dreaming — was caused by a localized disruption of brain activity. A new Yale study finds the entire […]

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A Promising New Form of Immunotherapy for Cancer

October 27, 2016

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New Approach to Cancer Treatment

New research suggests a way to increase the staying power of CAR T cells, a promising form of immunotherapy for cancer. In people with chronic infections or cancer, disease-fighting T cells tend to behave like an overworked militia — wheezing, ill-prepared, tentative, in a state of “exhaustion” that allows disease to persist. In a paper […]

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Yale Develops New Gene Editing Strategy to Correct Mutations

October 26, 2016

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New Gene Editing Strategy to Correct Mutations

Using a new gene editing strategy, researchers from Yale University can correct mutations that cause thalassemia, a form of anemia. Their gene editing technique provided corrections to the mutations and alleviated the disease in mice, the researchers said. The finding could lead to studies of a similar gene therapy to treat people with inherited blood […]

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Two-Pronged Immune Response Destroys Tumors

October 24, 2016

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New Treatment Elicits Two-Pronged Immune Response That Destroys Tumors in Mice

Using a combination of four different therapies, researchers from MIT reveal a new treatment that destroys tumors in mice. Harnessing the body’s own immune system to destroy tumors is a tantalizing prospect that has yet to realize its full potential. However, a new advance from MIT may bring this strategy, known as cancer immunotherapy, closer […]

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Neuroscientists Identify Two Key Groups of Neurons That Help Regulate Appetite

October 21, 2016

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Scientists Identify Two Key Groups of Neurons That Help Regulate Appetite

In a newly published study, Scientists from MIT have identify two key groups of neurons within the hypothalamus that help regulate appetite. MIT neuroscientists have discovered that brain cells called glial cells play a critical role in controlling appetite and feeding behavior. In a study of mice, the researchers found that activating these cells stimulates […]

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STEP Protein Linked to Alzheimer’s May Also Play a Role in Schizophrenia

October 18, 2016

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Protein linked to Alzheimer’s May Also Play a Role in Schizophrenia

New research from Yale University shows that an increase in the STEP (STriatal-Enriched protein tyrosine Phosphatase) protein leads to a disruption of synaptic function and contributes to cognitive disorders. A specific protein implicated in the cognitive decline of Alzheimer’s disease also appears to play a role in genetic predisposition to schizophrenia, meaning that a drug […]

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New Research Shows Female Hippocampus Structure Changes in Sync with Hormones

October 10, 2016

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Study Shows Female Brains Change in Sync with Hormones

New research from the Max Planck Institute shows that in women, in parallel to the rhythm of the level of estrogen across their menstrual cycle, the structures of the Hippocampus vary — a brain area that is crucial for memories, mood and emotions. Although it has already been known for some time that the brain […]

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Drepanosaurus – A Small Reptile with a Rearsome Finger

October 3, 2016

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Drepanosaurus a Cross between a Chameleon and an Anteater

A newly published study confirms that Drepanosaurus, a prehistoric cross between a chameleon and an anteater, was a small reptile with a fearsome finger. The second digit of its forelimb sported a massive claw. Scientists analyzed 212-million-year-old Drepanosaurus arm fossils that were discovered at the Hayden Quarry in Ghost Ranch, New Mexico. The researchers describe […]

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Memory Changes May Occur in Women Decades Earlier Than Previously Thought

September 28, 2016

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Study Shows Changes in Memory Tied to Menopausal Status

New research from the Brigham and Women’s Hospital reveals that reproductive stage, not simply chronological age, may contribute to changes in memory and brain function for women. Many women report forgetfulness and changes in memory as they transition to menopause. But studies that target participants who are 65 and older do not account for cognitive […]

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New Yale Studies Explore the Science of Cardiovascular Diseases

September 26, 2016

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Cardiologists Explore the Science of Cardiovascular Diseases

Yale University scientists detail how basic science research insights are key to future breakthroughs in cardiovascular disease. Professor of cardiology Martin A. Schwartz led two recently published studies that advance knowledge of the underlying biology of cardiovascular diseases, which are among the most common causes of chronic illness and death worldwide. The first study, published […]

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Genomic Regions That Set Humans Apart From Other Primates Carry Many Autism-Linked Mutations

September 22, 2016

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Autism and Evolution

New research from Harvard Medical School suggests that mutations in genetic regulatory elements may be important in both autism spectrum disorder and human evolution. Small regions of the genome where humans have diverged from chimpanzees contain a variety of mutations implicated in autism and other neurodevelopmental disorders, report Harvard Medical School researchers at Boston Children’s […]

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MIT Biologists Reveal How lncRNA Helps to Control Cell Fate

September 12, 2016

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Biologists Discover How RNA Helps Control Cell Fate

New research details how biologists from MIT deciphered the structure of one type of long noncoding RNA and used that information to figure out how it interacts with a cellular protein to control the development of heart muscle cells. Several years ago, biologists discovered a new type of genetic material known as long noncoding RNA. […]

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