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New Delivery Technique Enables Rapid Treatment for Inflammation

January 20, 2017

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New Technique Enables Rapid Delivery of RNA to Treat Colon Inflammation

A team of engineers has developed a new RNA delivery technique that uses short bursts of ultrasound to efficiently deliver RNA into cells, reducing colon inflammation. MIT and Brigham and Women’s Hospital researchers have demonstrated that they can deliver strands of RNA efficiently to colon cells, using bursts of ultrasound waves that propel the RNA […]

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Study Shows Aspirin Use Lowers the Risk of Pancreatic Cancer

January 9, 2017

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Aspirin Lowers Risk of Pancreatic Cancer

New research led by the Yale School of Public Health shows that regular use of aspirin lowers the risk for pancreatic cancer by almost 50 percent. Researchers studied patients with newly diagnosed pancreatic cancer at 37 Shanghai hospitals from December 2006 to January 2011. The 761 patients were interviewed in person about their use of […]

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FDA-Approved Drug Treats a Rare Cardiac Disease

December 15, 2016

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Cancer Drug Treats Rare Cardiac Disease

New research shows that a low-dose of the FDA-approved drug dasatinib improves heart function in Noonan syndrome. About 1 in 2,500 babies born in the United States each year have Noonan syndrome (NS), a genetic disorder that results in severe heart defects, among other symptoms. A mutation in a gene called PTPN11 which encodes for […]

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New Study Links Zika and Glaucoma

November 30, 2016

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Zika and Glaucoma Linked for First Time

A newly published study demonstrates for the first time that the Zika virus can cause glaucoma in infants who were exposed to the virus during gestation. Exposure to the Zika virus during pregnancy causes birth defects of the central nervous system, including microcephaly. Brazilian and Yale School of Public Health researchers had reported early during […]

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Do Community Factors Affect Your Weight?

November 18, 2016

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Does Where You Live Affect What You Weigh

A newly published study from Yale University shows that community-level factors may be associated with reduced adult obesity rates in counties within states that have a high adult obesity rate. Adult obesity rates in the United States have reached epidemic proportions, with one in four people considered obese. Yet, obesity rates vary considerably across states […]

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Researchers Find Antibody That ‘Neutralizes’ Zika Virus

November 8, 2016

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Study Finds Antibody That ‘Neutralizes’ Zika Virus

A team of researchers has isolated a human monoclonal antibody that in a mouse model “markedly reduced” infection by the Zika virus. The antibody, called ZIKV-117, also protected the fetus in pregnant mice infected with the virus, the researchers reported today in the journal Nature. Zika is believed to cause microcephaly, unusually small heads, and […]

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Scientists Identify Potential Treatment for Fatal Leptospirosis

November 7, 2016

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Researchers Identify Potential Treatment for Fatal Leptospirosis

New research on leptospirosis sheds light on how the disease causes death and reveals a potentially novel treatment. While rare in the United States, leptospirosis remains an important health threat for impoverished populations in developing countries, causing more than one million illnesses and 60,000 deaths annually. The reasons why leptospirosis causes life-threatening manifestations, such as […]

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MIT Engineers Design a New Weapon Against Bacteria

November 2, 2016

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Engineers Design a New Weapon Against Bacteria

An international team of engineers has developed an antimicrobial peptide that can destroy many types of bacteria, including some that are resistant to most antibiotics. Over the past few decades, many bacteria have become resistant to existing antibiotics, and few new drugs have emerged. A recent study from a U.K. commission on antimicrobial resistance estimated […]

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New Study Shows Resistance to Cancer Drugs Runs Deeper Than a Single Gene

October 20, 2016

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Resistance to Cancer Drugs Runs Deeper Than a Single Gene

A new study from Yale University shows that resistance to cancer drugs runs deeper than a single gene. Searching for more individual genes to predict responses to breast cancer therapy may not work, a new study suggests. Instead, scientists and clinicians need to pay attention to abnormalities in networks of genes, Yale researchers report in […]

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New Research Provides Hope for Better Wound Healing for Diabetics

October 17, 2016

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New Hope for Better Wound Healing for People with Diabetes

New research from the Max Planck Institute could lead to the development of new wound treatment methods for people with diabetes. Diabetics often have to contend with wounds that heal poorly. Researchers at the Max Planck Institute for Biology of Ageing, the CECAD Excellence Cluster and the Institute of Genetics of the University of Cologne […]

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Yale Researchers Reveal Genes Behind Aggressive Ovarian and Endometrial Cancers

October 11, 2016

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Researchers Find Genes Behind Aggressive Ovarian and Endometrial Cancers

Researchers from Yale University have defined the genetic landscape of rare, highly aggressive tumors called carcinosarcomas, pointing the way to possible new treatments. The findings are published in the early edition of Proceedings of the National Academy of Sciences. Endometrial and ovarian cancers are the most prevalent gynecologic tumors in women, with over 76,160 newly […]

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Researchers Identify a New Way to Suppress Lung Tumors

October 3, 2016

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A New Way to Suppress Lung Tumors

A team of researchers has identified a new blocking mechanism that acts more like a dimmer switch and potently inhibits lung tumor cell growth. Lung cancer cell growth depends on certain proteins that require the addition of sugar molecule chains to become active. Scientists have long thought that the addition of these sugar chains is […]

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MIT Scientists Develop New Method to Deliver Beneficial Bacteria to the GI Tract

September 20, 2016

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Researchers Develop New Method to Deliver Beneficial Bacteria to the GI Tract

By coating bacteria with polymer layers that protect them from the acids and bile salts found in the digestive tract, scientists from MIT have developed a new strategy for delivering large numbers of beneficial bacterial to the human gut. The human digestive tract contains trillions of bacteria, many of which help digest food and fight […]

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New T Cell Subsets Have Potential to Improve Cellular Therapy for Cancer

September 14, 2016

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Researchers Identify New T cell Subsets with Potential to Improve Cellular Therapy for Cancer

Researchers from the Yale Cancer Center have identified that two genes, NR4A1 and ABC transporters, mark a distinct subset of quiescent T cells within human tissues, and have developed methods to mobilize them into circulation for potential application in adoptive T cell therapy of cancer. The study is published in the Journal of Clinical Investigation. […]

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Study Reveals a Promising New Target to Treat Type 2 Diabetes

August 31, 2016

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Yale Study Reveals Protein to Target in Type 2 Diabetes

Scientists at Yale University reveal promising new target for drugs to treat type 2 diabetes. When the body’s cells don’t respond normally to insulin — a condition known as insulin resistance — blood glucose levels can increase, resulting in type 2 diabetes. Researchers have long known that insulin resistance is linked to defects in the […]

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Harvard Researchers Identify a Key Instigator in Lou Gehrig’s Disease

August 26, 2016

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Scientists Identify Instigator That Ignites Nerve Cell Damage in Lou Gehrig’s Disease

A team of scientists from Harvard Medical School has identified a key instigator of nerve cell damage in people with amyotrophic lateral sclerosis, a progressive and incurable neurodegenerative disorder. Researchers say the findings of their study, published in the journal Science, may lead to new therapies to halt the progression of the uniformly fatal disease […]

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New Reserach Reveals How Zika Virus Causes Fetal Brain Damage

August 24, 2016

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Yale Reserachers Discover How Zika Virus Causes Fetal Brain Damage

In a newly published study, researchers from Yale University report that infection by the Zika virus diverts a key protein necessary for neural cell division in the developing human fetus, thereby causing the birth defect microcephaly. The findings suggest that Zika virus might be susceptible to existing antiviral drugs that may prevent disruption to the […]

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New Yale Research Reveals Insights into Alcoholic Liver Disease

August 11, 2016

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New Insights into Alcoholic Liver Disease

A team of researchers at the Yale School of Public Health has identified a novel mechanism that protects the liver against the accumulation of fats and may represent a promising new therapeutic approach for treating and/or preventing alcoholic liver disease (ALD) and other fatty liver diseases. Professor Vasilis Vasiliou, chair of the Department of Environmental […]

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