Brain age indices have potential value as diagnostic biomarkers and ‘vital signs’ of brain health.
A study published in the journal Sleep shows that a deep neural network model can accurately predict the brain age of healthy patients based on electroencephalogram data recorded during an overnight sleep study, and EEG-predicted brain age indices display unique characteristics within populations with different diseases.
The study found that the model predicted age with a mean absolute error of only 4.6 years. There was a statistically significant relationship between the Absolute Brain Age Index and epilepsy and seizure disorders, stroke, elevated markers of sleep-disordered breathing (i.e., apnea-hypopnea index and arousal index), and low sleep efficiency. The study also found that patients with diabetes, depression, severe excessive daytime sleepiness, hypertension, and/or memory and concentration problems showed, on average, an elevated Brain Age Index compared with the healthy population sample.
According to the authors, the results demonstrate that these health conditions are associated with deviations of one’s predicted age from one’s chronological age.
EEG-Based Brain Age Reveals Hidden Disease Markers
“While clinicians can only grossly estimate or quantify the age of a patient based on their EEG, this study shows an artificial intelligence model can predict a patient’s age with high precision,” said lead author Yoav Nygate, senior AI engineer at EnsoData. “The model’s precision enables shifts in the predicted age from the chronological age to express correlations with major disease families and comorbidities. This presents the potential for identifying novel clinical phenotypes that exist within physiological signals utilizing AI model deviations.”
The researchers trained a deep neural network model to predict the age of patients using raw EEG signals recorded during clinical sleep studies performed using overnight polysomnography. The model was trained on 126,241 sleep studies, validated on 6,638 studies, and tested on a holdout set of 1,172 studies. Brain age was assessed by subtracting individuals’ chronological age from their EEG-predicted age (i.e., Brain Age Index), and then taking the absolute value of this variable (i.e., Absolute Brain Age Index). Analyses controlled for factors such as sex and body mass index.
“The results in this study provide initial evidence for the potential of utilizing AI to assess the brain age of a patient,” said Nygate. “Our hope is that with continued investigation, research, and clinical studies, a brain age index will one day become a diagnostic biomarker of brain health, much like high blood pressure is for risks of stroke and other cardiovascular disorders.”
The research abstract was published recently in an online supplement of the journal Sleep and was presented as a poster during Virtual SLEEP 2021. SLEEP is the annual meeting of the Associated Professional Sleep Societies, a joint venture of the American Academy of Sleep Medicine and the Sleep Research Society.
Reference: “543 EEG-Based Deep Neural Network Model for Brain Age Prediction and Its Association with Patient Health Conditions” by Yoav Nygate, Sam Rusk, Chris Fernandez, Nick Glattard, Jessica Arguelles, Jiaxiao Shi, Dennis Hwang and Nathaniel Watson, 3 May 2021, Sleep.
DOI: 10.1093/sleep/zsab072.541
This study was supported by EnsoData, a healthcare artificial intelligence (AI) company. EnsoData’s initial product, EnsoSleep, is an AI scoring and analysis solution that provides automated event detection in sleep studies.
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