Researchers from Flinders University, along with international experts, have discovered that the PF4 antibodies causing VITT after adenovirus vector-based COVID-19 vaccination share identical molecular signatures with those found in similar cases following natural adenovirus infection. This finding, using a new approach developed at Flinders, has significant implications for understanding the genetic risk factors and improving future vaccine development.
New research has shown that the dangerous PF4 antibodies involved in vaccine-induced thrombosis (VITT) and similar disorders from common cold infections share identical molecular structures, highlighting implications for future vaccine development and disease management.
New research conducted by Flinders University and global specialists is deepening our knowledge of vaccine-induced immune thrombocytopenia and thrombosis (VITT). During the peak of the COVID-19 pandemic in 2021, VITT was recognized as a new condition linked to adenovirus vector-based vaccines, particularly the Oxford-AstraZeneca vaccine.
VITT was found to be caused by an unusually dangerous blood autoantibody directed against a protein termed platelet factor 4 (or PF4). In separate research in 2023, researchers from Canada, North America, Germany, and Italy described a virtually identical disorder with the same PF4 antibody that was fatal in some cases after natural adenovirus (common cold) infection.
Flinders University researchers Dr. Jing Jing Wang and Flinders Professor Tom Gordon, Head of Immunology at SA Pathology in South Australia, led a previous study in 2022 that cracked the molecular code of the PF4 antibody and identified a genetic risk factor related to an antibody gene termed IGLV3.21*02.
Flinders University immunology researchers Dr. Jing Jing Wang and Professor Tom Gordon. Credit: Flinders Foundation
Collaborative Efforts and Future Implications
Now, the Flinders group has collaborated with this international group of researchers to find that the PF4 antibodies in both adenoviruses infection-associated VITT and classic adenoviral vectored VITT share identical molecular fingerprints or signatures.
The research will also have implications for improving vaccine development, says Flinders University researcher Dr. Wang, the first author on the new article that was published in the eminent New England Journal of Medicine.
“These findings, using a completely new approach for targeting blood antibodies developed at Flinders University, indicate a common triggering factor on virus and vaccine structures that initiates the pathological pF4 antibodies,” explains Professor Gordon.
“Indeed, the pathways of lethal antibody production in these disorders must be virtually identical and have similar genetic risk factors. Our findings have the important clinical implication that lessons learned from VITT are applicable to rare cases of blood clotting after adenovirus (a common cold) infections, as well as having implications for vaccine development,” he says.
Reference: “Antibody Fingerprints Linking Adenoviral Anti-PF4 Disorders” by Jing Jing Wang, Linda Schönborn, Theodore E. Warkentin, Tim Chataway, Leonie Grosse, Paolo Simioni, Stephan Moll, Andreas Greinacher and Tom P. Gordon, 15 May 2024, New England Journal of Medicine.
DOI: 10.1056/NEJMc2402592
The research was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft) and a European Medicines Agency service contract. Dr. Schönborn was supported by the ASH Global Research Award from the American Society of Hematology and by the Gerhard Domagk Research Program through the Medical University of Greifswald. Dr. Wang was supported by a Flinders Foundation Health Seed Grant.
all the people who forced vaccines on others need to be hanged
Ya, the Trump administration did this.
OK, Karen….
WRONG.
Seriously, how is it wrong? The vaccine mandates were during the Trump administration.
Presidents have no say over local policies, Cletus.
EVERY lockdown was by Demunists.
Hope you enjoyed that single term your bio weapon bought for you. It will be decades, if ever, before anyone trusts your party with power again.
Go back and look at a calendar, moron.
Your statement is clearly not true. I think you may be living on another planet…
WRONG, the mandates were all done under the Biden administration when he tried to mush it through OSHA in 2021 well after Trump left office.
So in conclusion the healthy appearing little girl dissected skinned and minced for science was made sick with adenovirus put in a bath of calf blood serum and sprinkled with fish semen. What could go wrong with this recipe other than the minced kidney could be a neuron and the calf semen could have been contaminated and the fish semen well I’ll leave that up to science? Anyway I think one of them said it wasn’t really for anything other than to see if it could be done.
This cell line is a transformed cell line and as such is classified as a Genetically Modified Organism (GMO). The Human Embryonic Kidney cell lines have been transformed with Human Adenovirus 5.
You don’t have to be a biological researcher to know that the developers of mRNA vaccines don’t know WTF they are doing.
Or they knew/know exactly what they are doing. And just didn’t think they’d get CAUGHT.
The fruits of Malice and Ineptitude are virtually indistinguishable.
If you read the article you’ll see that this condition was not caused from the mRNA vaccines but rather from the vaccine that used an adenoviral vector.
Only those who were complicit or willfully blind could be surprised at this headline.
Rightly so. Most of us are sheeple to be driven easily.
Said it from the first. Being proven RIGHT every day since.
The mRNA jabs do NOT create immunity against any actual pathogen, they induce AUTOIMMUNITY, turning your immune system against your own body’s cells.
If you read the article you’ll see that this condition was not caused from the mRNA vaccines but rather from the vaccine that used an adenoviral vector.
Whatever you say Dr Fauci…
Seriously, READ the article. It says, “During the peak of the COVID-19 pandemic in 2021, VITT was recognized as a new condition linked to adenovirus vector-based vaccines, particularly the Oxford-AstraZeneca vaccine”.
If you believe that THIS article is proving your belief RIGHT, I think you should go and reevaluate all the other instances where you believe you were also proven right.
It seems people will twist and even simple, straightforward information or articles to suit their narrative, no matter how far from reality it actually becomes…
@Pelosi’s Hammer – you really think they don’t know what they are doing? They know exactly what they are doing. It seems you don’t get it.
My long-time (unfortunately now retired) primary care physician said, (paraphrasing) “Whenever possible I never prescribe any medication which has not been on the market for 20 years. All medications have side effects, and we know what they are in those long-established meds.”
I also am old enough to remember thalidomide, and remember seeing many young college-age students in Germany as I traveled extensively there in 1980-81.
I and my family did not take the Covid jab. As my 34 year old grandson recently said, he knows many people his age who regret taking the jab, but he knows no one who did not take the jab who now is sorry.
Only you and your close loved ones care about you. One must think for themselves and carry out due diligence before buying into the common hype. Corporations are soulless, the government is not your friend, lying now is a badge of honor. A strain of evil lies in the hearts of mankind and as a society we have shed the restraints on that evil.
Want to know the breakdown of nearly any social question, simply overlay the question with the Bell curve to see how the way things fall out percent wise. That includes intelligence, awareness, curiosity, concern for others, financial planning, due diligence, independence, and on and on.
Also, the “Strauss–Howe generational theory” https://en.wikipedia.org/wiki/Strauss%E2%80%93Howe_generational_theory led to their 1997 book “The Fourth Turning,” which is well worth taking the time to read and contemplate.
I repeat, corporations are soulless and government is not your friend. Only you and your closest loved one really care about you. Become aware, think for yourself, carry out due diligence before jumping on a bandwagon.
Don’t be putting foreign stuff into your body if you are not clear on what may result from your action.
My wife and I had Covid at 79 years old. We were prepared with ivermectin and followed as best we could the FLCCC Alliance https://covid19criticalcare.com/ protocol and suffered only minimal effects. We recognized the red flags early on as Big Pharma, the government, and our corrupted medical system started flogging the deadly nature of Covid and pushing the vaccine. Luckily we had found a moral physician who provided advice and necessary prescription in preparation.
By the way, remember the push against chloroquine and hydroxychloroquine? Well, in 1979 I accepted a position working in the Indonesian part of New Guinea. My wife, pre-teen son, and I started taking chloroquine two weeks before departing the States and continued taking continuously it for more than two years. Over the years my wife and I spent considerable time traveling in Southeast Asia, where malaria is endemic, and each time took chloroquine as a preventive. We never caught malaria or suffered any side effects. We now are healthy at 82.
Don’t be a lemming, folks. Be aware, carry out some due diligence, and think for your self.
Congrats to you and your wife for not drinking the Kool-Aid.
Just a note. We know Democrats funded this bio weapon for over 20 years, developing it in secret with their CCP allies. All that is NOT known is EXACTLY how it got out.
Now, they are pushing the accident story hard – but it doesn’t wash. In over 5,000 years of recorded human history, there is little or no evidence there has ever been such a thing as a “political coincidence.” Absent proof it did not escape accidentally, the almost certain conclusion is that someone let it out on purpose. That leaves China or the DNC.
China risked global thermonuclear war had they released it. So, who does that leave?
Hi JonSEAZ
Here’s an article about the hundreds, thousands, uncountable number of people who were in a hospital bed unable to breath, telling reporters they wish they had gotten the vaccine.
Remember: you can believe what you want if you stay in your echo chamber. But you will be bombarded by contradicting evidence when you scuttle out of it.
https://www.nbcnews.com/health/health-news/unvaccinated-hospitalized-patients-say-they-regret-not-getting-shot-n1273342
None of this is surprising to anyone in the field of virology. We knew early on this was a manufactured virus as it contained a furin cleavage site which was not naturally occurring in this family of viruses. All of the related and unusual side effects attributable to Coronavirae, namely autoimmune induced myocarditis, thrombosis, etc. were likely to occur with the vaccine and/or infection. That the political arms of medicine, namely big pharma, CDC, FDA, NIH, deliberately surpressed this likely outcome was and remains criminal.
This calls for Hague trials for every single decision maker who participated in making this experimental drug mandatory.
Wait, I was supposed to be a conspiracy theorist when I brought up this topic a couple years ago. Did I just get demoted?
The adenovirus used to carry the viral payload in the vaccine was not a human one. The vector is a chimpanzee adenovirus modified to avoid its replication. So it is not a “common cold virus”, though it may be a member of the same virus family. If a common cold adenovirus had been used, many humans would have mounted an immune response to the vector instead of the payload, rendering the vaccine ineffective. Still, with the benefit of hindsight, who’d have though “what could possibly go wrong with using a chimp virus?” OOPS! And AZ just withdrawn its vaccine worldwide.
Having said that, the consequences of infection with early variants of Covid-19 are almost certainly way worse on average than those of the vaccine. But I do think we were panicked into taking it, with the risks due to the vaccine being played down (or not yet known) and so informed consent was not properly obtained. In terms of lives saved it looks like a good job. Er, but what about this brain fog and these achey joints and muscles?
so someone figured out how they killed all those people … the govt is very crafty