Scientists Grow “Synthetic” Embryo With Brain and Beating Heart – Without Eggs or Sperm

Natural and Synthetic Embryos Comparable Brain Heart

Natural and synthetic embryos side by side show comparable brain and heart formation. Credit: Amadei and Handford

Scientists from the University of Cambridge have created model embryos from mouse stem cells that form a brain, a beating heart, and the foundations of all the other organs of the body. It represents a new avenue for recreating the first stages of life.

The team of researchers, led by Professor Magdalena Zernicka-Goetz, developed the embryo model without eggs or sperm. Instead, they used stem cells – the body’s master cells, which can develop into almost any cell type in the body.

“It’s just unbelievable that we’ve got this far. This has been the dream of our community for years, and major focus of our work for a decade and finally we’ve done it.” — Magdalena Zernicka-Goetz

By guiding the three types of stem cells found in early mammalian development to the point where they start interacting, the researchers mimicked natural processes in the lab. The scientists were able to get the stem cells to ‘talk’ to each other by inducing the expression of a particular set of genes and establishing a unique environment for their interactions.

The stem cells self-organized into structures that progressed through the successive developmental stages until they had beating hearts and the foundations of the brain They also had the yolk sac where the embryo develops and gets nutrients from in its first weeks. Unlike other synthetic embryos, the Cambridge-developed models reached the point where the entire brain, including the anterior portion, began to develop. This is a further point in development than has been achieved in any other stem cell-derived model.

According to the team, their results could help researchers understand why some embryos fail while others go on to develop into a healthy pregnancy. In addition, the results could be used to guide the repair and development of synthetic human organs for transplantation. The study, which is the result of more than a decade of research that progressively led to more and more complex embryo-like structures, was reported on August 25, 2022, in the journal Nature.

Natural and Synthetic Embryos

Natural and synthetic embryos side by side show comparable brain and heart formation. Credit: Amadei and Handford

“Our mouse embryo model not only develops a brain, but also a beating heart, all the components that go on to make up the body,” said Zernicka-Goetz, Professor in Mammalian Development and Stem Cell Biology in Cambridge’s Department of Physiology, Development and Neuroscience. “It’s just unbelievable that we’ve got this far. This has been the dream of our community for years, and major focus of our work for a decade and finally we’ve done it.”

A “dialog” between the tissues that will form the embryo and the tissues that will connect the embryo to the mother is necessary for the healthy development of a human embryo. Three different stem cell types begin to form in the first week following fertilization; one of these will eventually develop into the bodily tissues, while the other two support the embryo’s development. One of these extraembryonic stem cell types will become the placenta, which connects the fetus to the mother and provides oxygen and nutrients. The second is the yolk sac, where the embryo grows and where it gets its nutrients from in early development.

Many pregnancies fail at the point when the three types of stem cells begin to send mechanical and chemical signals to each other, which instruct the embryo on how to develop properly.

“So many pregnancies fail around this time, before most women realize they are pregnant,” said Zernicka-Goetz, who is also Professor of Biology and Biological Engineering at Caltech. “This period is the foundation for everything else that follows in pregnancy. If it goes wrong, the pregnancy will fail.”

Magdalena Zernicka-Goetz

Professor Zernicka-Goetz in the lab. Credit: University of Cambridge

Professor Zernicka-Goetz’s group in Cambridge has been studying these earliest stages of pregnancy over the past decade, in order to understand why some pregnancies fail and some succeed.

“The stem cell embryo model is important because it gives us accessibility to the developing structure at a stage that is normally hidden from us due to the implantation of the tiny embryo into the mother’s womb,” said Zernicka-Goetz. “This accessibility allows us to manipulate genes to understand their developmental roles in a model experimental system.”

To guide the development of their synthetic embryo, the scientists put together cultured stem cells representing each of the three types of tissue in the right proportions and environment to promote their growth and communication with each other, eventually self-assembling into an embryo.

The research team discovered that the extraembryonic cells signal to embryonic cells by chemical signals but also mechanistically, or through touch, guiding the embryo’s development.

“This period of human life is so mysterious, so to be able to see how it happens in a dish – to have access to these individual stem cells, to understand why so many pregnancies fail and how we might be able to prevent that from happening – is quite special,” said Zernicka-Goetz. “We looked at the dialogue that has to happen between the different types of stem cell at that time – we’ve shown how it occurs and how it can go wrong.”

A major advance in the study is the ability to generate the entire brain, in particular the anterior part, which has been a major goal in the development of synthetic embryos. This works in Zernicka-Goetz’s system because this part of the brain requires signals from one of the extraembryonic tissues to be able to develop. The team thought that this might be taking place from their 2018 and 2021 studies, which used the same component cells to develop into embryos at a slightly earlier stage. Now, by pushing development just one day further, they can definitively say that their model is the very first to signal development of the anterior, and in fact the whole, brain.

“This opens new possibilities to study the mechanisms of neurodevelopment in an experimental model,” said Zernicka-Goetz. “In fact, we demonstrate the proof of this principle in the paper by knocking out a gene already known to be essential for formation of the neural tube, precursor of the nervous system, and for brain and eye development. In the absence of this gene, the synthetic embryos show exactly the known defects in brain development as in an animal carrying this mutation. This means we can begin to apply this kind of approach to the many genes with unknown function in brain development.”

While the current research was carried out in mouse models, the researchers are developing similar human models with the potential to be directed towards the generation of specific organ types to understand mechanisms behind crucial processes that would be otherwise impossible to study in real embryos. At present, UK law permits human embryos to be studied in the laboratory only up to the 14th day of development.

If the methods developed by Zernicka-Goetz’s team are shown to be successful with human stem cells in the future, they could also be used to guide development of synthetic organs for patients awaiting transplants.

“There are so many people around the world who wait for years for organ transplants,” said Zernicka-Goetz. “What makes our work so exciting is that the knowledge coming out of it could be used to grow correct synthetic human organs to save lives that are currently lost. It should also be possible to affect and heal adult organs by using the knowledge we have on how they are made.

“This is an incredible step forward and took 10 years of hard work of many of my team members – I never thought we’d get to this place. You never think your dreams will come true, but they have.”

Professor Magdalena Zernicka-Goetz has made an incredible scientific breakthrough.

The creation of synthetic mouse embryos in a test tube that develop brains and beating hearts, starting only with embryonic stem cells, is the culmination of a decade’s work.

Magda explains:

I’m fascinated by the mystery of how embryos work. Every embryo follows a similar journey: one cell becomes many, then they communicate with each other and arrange themselves to form a structure that will provide a blueprint for all adult body parts. But how do embryo cells decide their fate, how do they know where to go and what to do? How do they form the right parts in the right place at the right time?

Building the first ‘synthetic embryo’ models was a process we achieved step by step. Setting out, we knew that embryonic stem cells could be cultured indefinitely in the lab, and that when they’re injected into an embryo they can potentially contribute to any tissue in the adult organism. The challenge was to guide them to develop into a complete embryo. In addition to the embryonic stem cells we used two kinds of extraembryonic tissue: one of which forms the placenta and the other a sac in which the embryo develops. These tissues are very important, as they send signals to the embryo to develop all its parts at the right time and in the right place.

Combining stem cells representing each of these three types of tissue is easier said than done. We had to find an environment where all three distinct cell types could grow and communicate with each other. And we had to find the right proportions of each cell type, and add them in the right sequence. Once we established these basic principles, the stem cells did the rest: they self-organized to progress through successive developmental stages until they had beating hearts and the foundations for a brain.

The key to our achievement was thinking outside the conventional box. The majority of embryo model studies focus on embryonic stem cells, but don’t consider the significant role of extraembryonic cells. We mixed the right proportions of both embryonic and extraembryonic stem cells. Extraembryonic cells signal to embryonic cells through different means, by chemical signals but also mechanistically ‘by touch’. Our studies are helping to understand these signaling events.

We are developing an analogous model of the human embryo, to understand the mechanisms behind crucial processes that would be otherwise impossible to study. This is important because the great majority of human pregnancies fail at this developmental stage, due to causes that we don’t understand. It will also allow us to identify factors permitting development of healthy human tissues as they form different organs.

Creating the new ‘synthetic embryo’ has taught us a lot about the mechanisms by which the embryo builds itself. We learned how the extraembryonic tissues direct the embryonic stem cells along the right pathways to signal formation of the correct structures; how cells move between compartments as the multi-layered body plan arises; and how this correctly sets the scene for neurulation — the process where tissue folds to form the neural tube and, in turn, the brain and spinal cord.

This model gives us access to the developing structure at a stage that’s normally hidden from us, when the tiny embryo implants into the mother’s womb. Our model does not have to implant to develop, so it remains completely visible to us, allowing us to see the embryo’s progression through that developmental stage. This accessibility allows us to manipulate genes to understand their developmental roles in a model experimental system.

It’s certainly true that carrying out this type of work requires passion and resilience. I grew up in Poland under a Communist regime, which meant that traveling wasn’t allowed and thinking differently was not encouraged. There was immense social pressure to conform, and a lot of us rebelled against that. A silver lining of this was a desire to think independently and to persevere despite discouragement. That shaped me as a scientist too.

When I started my research group in Cambridge, I established ways to study the ‘developmental black box’ — the development of the embryo at the time of implantation. My mentors had discouraged me from pursuing it during my PhD because they were concerned it would be difficult to shine light inside this ‘box.’ But I was so taken by the question of how the embryo self-organizes that I didn’t give up and, inch by inch, we have worked our way forward.

My advice to all young scientists is to follow your heart. Study a topic that inspires you, and choose an advisor who can be supportive of your style of work. In my opinion, it’s important to guide young scientists in the lab, but also to give them space to explore their individuality. My experience is that the challenges for female scientists increase as they progress through their careers. At later stages, it’s critical to have mentors who understand not only science but also how to balance it with everyday life, including starting a family.

During my own pregnancy, I was shocked when an early screening showed abnormalities. The sampling was of extraembryonic cells so I waited for the amniocentesis, which samples fetal cells that have fallen into the amniotic fluid. These were normal, which put my mind at ease. The experience led me to study mosaic aneuploidy — a condition in which the embryo has cells with the wrong number of chromosomes alongside chromosomally normal cells. Incredibly, we found that these abnormal cells can be eliminated, and the normal, healthy cells compensate for their absence. For some reason, this mechanism doesn’t operate in the tissues that build the placenta, and we’re still trying to understand why and how.

Science is demanding, it’s hard work and it takes away most of your waking hours. I switch off by watching films — I watch a lot of foreign films in Polish, French, and Danish, and documentaries and art films. But when I want to lose myself in another narrative, I watch dramas. I’m also a recent convert to gardening, where I can encourage the successful development of other life forms!

It is an incredible feeling and a privilege to have this direct insight into the origins of a new life. It’s like discovering a new planet that we didn’t know existed.

For more on this research, see Scientists Grow “Synthetic” Mouse Embryo With Brain and Beating Heart.

Reference: “Synthetic embryos complete gastrulation to neurulation and organogenesis” by Gianluca Amadei, Charlotte E. Handford, Chengxiang Qiu, Joachim De Jonghe, Hannah Greenfeld, Martin Tran, Beth K. Martin, Dong-Yuan Chen, Alejandro Aguilera-Castrejon, Jacob H. Hanna, Michael Elowitz, Florian Hollfelder, Jay Shendure, David M. Glover and Magdalena Zernicka-Goetz, 25 August 2022, Nature.
DOI: 10.1038/s41586-022-05246-3

207 Comments on "Scientists Grow “Synthetic” Embryo With Brain and Beating Heart – Without Eggs or Sperm"

  1. It all sounds so wonderful and uplifting to be able to create organs for people or to assist in pregnancy retention.
    Just because we can, should we?
    There will come a time, soon, when people will realize we’ll be extinct by the end of the century.
    No one should be having children anywhere anymore.

    • This is an extremely poor take on our current situation in the world.
      The only thing that would guarantee we go extinct any time soon would be if people stop having children.
      The advancement of technology and life sciences are what will help us solve the problems coming on the horizon for humanity. An aging world population due to the overpopulation misconception is doing more harm that people give credit.

      • You’re right, quad. It creates a bigger burden on the health care system. As long as enough food is being produced, the human population can keep growing indefinitely

        • I think the invention of better harvesters and such has allowed the population to boom. Poor countries like India with rapidly increasing populations are making progress in human rights and becoming wealthier.

  2. And just like that, Blade Runner becomes prophecy!

  3. Earlier the Better | August 27, 2022 at 9:58 am | Reply

    Photos are Magnificient; People walked down the other road until now…Business captured Soul. Get back to the right road right now, because those of the future will definitely do so, even if we miss the direction now.

  4. derrr derrr science | August 27, 2022 at 12:22 pm | Reply

    OMG now synthetic materials can’t be aborted.

  5. Will they let it grow to term? See if it becomes an actual mouse, or just kill it while it’s developing?

  6. Germans never stop in creation ubermenchen. In lack of humans so far they must be satisfied with mouse.

  7. This is Unnatural Satanic Practice. EVIL Scientist. God will destroy all of this Abomination. Jesus is Coming Soon.

  8. Oh being a medical staff has been a dream which I believe will form late when I stop living for others such as Shards,Budu,Ronnie,Chan see I become a victim because I didn’t know what’s going on see I am only a Dr. Not engineer,Supplier oh English falculty as a professor is likely see I am prohibited from learning biology oh powder given chemicals too has been a burden later

  9. The beautiful irony of an oppressed young women from a stultifying communist country gleaning the processes that result in embryonic structural differentiation is inspiring beyond words.

  10. This should make us weep! This illustrates, perhaps, the most important reason that education throughout the world should NOT be secular. In general, humanity does not know when to stop. All life belongs to God. We are arrogantly crossing the line in many ways. Especially, the most intellectually gifted among us seem determined to ignore the fine print for our existence in this holy place.

    • You’ve made me so sad. It hurts that religion has turned you into a informercial for that which is against humanity.

  11. Tabitha Johnson | August 28, 2022 at 1:40 am | Reply

    These are admirable goals and i love the proactive compassion that drives you. However i simply cannot support this particular method to achieve your goals. These are not “models” but babies. If it has a heart beat and organs so good that they are harvested? it’s a life. This sounds like a puppy mill but far worse. pumping out countless babies so that you can dice them up and sell their body parts-all while hiding behind this ‘synthetic embryo’ nonsense. As far as this has gotten is beyond me. To have babies already in your lab waiting for their turn to be experimented on absolutely horrifies me.

  12. Not cool, leave it alone. You are playing with fire.

  13. Where is your god now?

  14. Playing God and screwing with life not a good idea it might be a noble cause to help with organ transplants but who guarantees this man-made unnatural “thingy” will just do that? I find it abhorrent. One day we will (apparently they are already doing it in labs in Asia) we will have crossbreeds of humans and animals… chimeras …or only God knows. Look at the magnificent work done with creating COVID in a lab … We are just fools.

    • I’m not a particularly religious person, but I would think that for a compassionate God that the human suffering that could be alleviated through animal research like this would win out. Humans will never possess the power of God, just look at the scale of how big space is. On a side note, COVID wasn’t created in a lab although it could’ve escaped from one. Anyone that truly cares about life should be considerate of vulnerable people that can’t buy necessities because of COVID. 6 mil+ dead that suffocated to death alone. If you don’t think this is the biggest global tragedy in years, then either you are fortunate enough to not be personally affected by it or you are pretending not to see..

  15. Horrible! Why are you trying to play God! Makes me sick! | August 28, 2022 at 5:13 am | Reply

    Horrible! Why are you trying to play God! Makes me sick!

  16. Don’t forget to feed him french fries
    he loves her

  17. Please shut up with your god crap. There is no god you moronic delusional hypocrites. Do you insecure pathetic people really think just because you think it, it’s true. Religion is the real threat to humanity. It was invented to keep the dumb masses in line. I can’t believe with all the knowledge that we posses people still believe a fairy tale. Stop telling everyone else how they have to live according to your pathetic beliefs. Religion is responsible for more suffering and atrocities than all of the so-called evil combined throughout time. Get a grip losers.

    • I’m not religious; however, God is omniscient, and you’re not. So you’re little lab stuff can offset things in our world. You know like what happen with our 💧 water with science all kinds if chemicals now dumped in it ruining it. There is a corrupt side to science.☠

    • HIstory tells a different story | August 28, 2022 at 12:46 pm | Reply

      Actually that is false and NOT supported by history… atheism, communism, secular humanism, and other forms of tyranny and dictatorships have been the cause of FAR MORE deaths throughout history. Get your facts straight.

      • Are you high? God has killed billions. The flood, miscarriages , the inquisition, Jim Jones, Joel ostensibly, god sending fourth bears to eat kids, the only thing more pathetic than religion are it’s followers, particularly evangelicals.

      • Secular humanism isn’t the same as a dictatorship. A totalitarian dictatorship can’t, by definition be humanist because it violates human rights

    • Strange how a lot of religious right wingers don’t care about all the death and suffering that’s going on around them in the past couple years. 6 million people+ have suffocated to death with no family but all I hear is conspiracy garbage from people instead. Or worse yet apathy from people that aren’t affected by it at all. I just hope they change their mind, and I guarantee they would when their immediate family members are stuck in hospitals suffocating and they can’t visit..

      • I’ll add that most religious people are decent human beings, I don’t think a lot are necessarily hateful, just blinded by their beliefs.

    • It’s better to live this life believing there is God and die finding out there isn’t than to live this life believing there is no God, then die later to find out there is God

  18. Y’all are not God stop playing God please

  19. The new Nephillium. This is what caused the great flood. And the violence.

  20. What is this contributing to society exactly?

  21. Hurry up and make this useful and grow me a pancreas that works so I don’t have to be a type 1 diabetic anymore.

    • Eternal God can easily do that for you before tommorow if you believe strongly in him and you’ve given your life to him, I bet it.

    • Robert Rosenkranz | August 30, 2022 at 3:23 pm | Reply

      I found a new health discovery of a human cell regeneration technology. Got my friends pancreas working in 3 months … It did not work for 11 years. Now he no longer has to take insulin shots.. Love this technology.

  22. I sure hope a lot of wonderful medical discoveries are made as a result of this. I hope the discoveries and confirmations to existing knowledge lead to many advancements in medical science to allow us and future generations to be healthier and to cure many diseases. I’m praying this is the case and I’m praying for the Lord’s protection and guidance. I know He works through amazing ways, and this is a pretty amazing feat you’ve accomplished. Congratulations! Keep your pure intentions, integrity, and wisdom in tip top shape and I’m confident everything will work out great. *Insert high five here*

  23. They need future workers to not technically be human

    Never again will they have to be concerned about human rights

    They are phasing us out

    The useless eaters are an outdated model

    Hurry down to get your death shot

  24. What’s your state say about how long before you’ll be imprisoned for murder when you abort it?People never fail to amaze me with their hypocrisy.Go science!🤯

    • Abort what? This is mouse not human DNA they are working with. All they are doing is cloning a mouse using stem cells. If they can use stem cells to reproduce organs people need for transplants this could be really helpful. As a diabetic I would love to see a new organ grown for me that will mean I am no longer a diabetic even if I have to get a new one every 5-10 years.

      • You are absolutely right, countless lives could be saved using artificially grown organs. When I see people argue that God doesn’t want this, I can’t help but think, wouldn’t that be cruel on God’s part? To not want people to try and prevent suffering.

        • God isn’t cruel, it because man has forgotten his Creator, they’ve gone astray and they look for their own means of solving problem, he is omniscient, he said let us make man in our own image and likeness, money does not make a man, fame doesn’t , man don’t make man, GOD MAKES MAN. Every man was born with eyes and nose but no man was born with the knowledge of God. We’re meant to seek him. The devil he very corny, he had always wanted to be like God, but God has always wanted man to be like him not angels, again; God said let us make MAN in our own image and likeness not angels, don’t be like God through technology, be like God through God, we should seek him and definitely If we can ignore the devil’s devises we can grow up to God, God already promised us his life, which is His gift to us; ETERNAL LIFE, we can’t achieve this through the devil, as I write this to the whole world the devil speaks currently to those reading this, he is a thief not an armed robber, when he steals, you don’t know. Great men demystify mysterys of God not in a kind of way like this, the only way is Christ, Christ said he is the way, truth and life, there is this message this meek animal has been passing to humans since ages that people don’t know of, and that’s the lamb 🐑,, it bleats right: mee!, mee!, It’s actually calling out to MEN(humanity). Christ is as meek as the lamb

        • Prayer is good, and certainly doesn’t hurt anything, and I do believe that God is good, but I think at some point actions count for more than beliefs alone. If I were to get in a car wreck, and be seriously hurt, then I’m pretty confident that I would get better results from calling 911 and going to the hospital then just praying. If I died, then I probably would wish I had prayed, I don’t mean to dispute that at all. There are certain sects that are against blood transfusions and there has been controversy when parents refused to allow their kids to get blood. I don’t feel like that’s fair to the kid. I just don’t think it’s fair to not do everything in our power, as a society, to help people that, say, need an organ.

  25. Dennis Johnson | August 28, 2022 at 7:49 am | Reply

    I’m loving it. It helps out humanity and in the process drives the religious nuts crazy. 10 to 1 if any of these religious hypocrites ever needed a transplant, they would be the first to jump in line for it when the rubber meets the road.
    As for me, if they could hurry up so that I am no longer a diabetic, count me in. Slice and dice away.

    • Why would this drive religious nuts crazy? You are cloning organs that already exist not creating a new life.

      • I’m not religious; however, God is omniscient, and you’re not. So you’re little lab stuff can offset things in our world. You know like what happen with our 💧 water with science all kinds if chemicals now dumped in it ruining it. There is a corrupt side to science unfortunately.

      • My thoughts exactly John

    • If they have a heart beat then America see it as they are alive, are we going to kill them then so others can live? Science has always gone to far. People are born and people die this is the normal course of life. Why can’t we except that? My 6month old granddaughter died and yes it was hard to go through but it’s called life. No explanation she died in her sleep. We keep messing with nature and we will destroy everything good in this world! Abortion bands everywhere but we can create a human from stem cells and justify murder for it’s body parts. Humans are sad! Desperate!!! Before I allow this world to turn me into a IRobot or a Alien breed I will have to pass and die naturally. When is enough enough. We will destroy this world one way or another! Scientist will see to this fact! Stop experimenting with fait. Money is all humans see. Enjoy the life we have, don’t take it for granted, and appreciate we everyday we have on earth. Stop the madness!

  26. Man trying to act like God again, they think they are so smart with there measly little brain 🧠.

    • Well if your god really exist he is pretty weak for a god if he didn’t foresee humans using their technology to do something like this.

      That leaves 2 possibilities, 1 god isn’t real or your god isn’t as powerful as you think he is and he can’t control or create things.

  27. Modern day Frankenstein

  28. Let me get this straight. Murder babies in the womb and call it “good”. Then geneticly create in a tube no parents whatsoever and call upon no creator. Turn them loose. Sounds so agenda 21/ great reset to me. No morals , no consequences. Anyone here ever read “The Giver” or any books at all? The Bible would be a even better start. If you don’t believe in God, there is still a set of standards and moral from time untold to be considered.

  29. This is pure evil and madness.

  30. Dr.Elizabeth T Strauss,Esq. | August 28, 2022 at 8:50 am | Reply

    Totally unimpressive and downright inept! Development of Embryo from a Mouse stem cells-probably a big giant mouse will be reproduced by this “Professor” IF that Embryo will develop firther than the very first stage of such!

  31. Well, that’s that then. Science has finally gone too far.

  32. Eugenics profiling laws incoming soon as the ethics board is coming soon.

  33. Basic Waffle
    Recipe courtesy of Alton Brown

    Basic Waffle
    Total Time:
    30 min
    15 min
    5 min
    10 min
    Yield:approximately 6 (8-inch round) waffles

    4 3/4 ounces all-purpose flour, approximately 1 cup (135g)
    4 3/4 ounces whole-wheat flour, approximately 1 cup (135g)
    1/2 teaspoon baking soda
    1 teaspoon baking powder
    1 teaspoon salt
    3 tablespoons sugar (38g)
    3 whole eggs, beaten
    2 ounces unsalted butter, melted (57g)
    16 ounces buttermilk, room temperature
    Vegetable spray, for waffle iron

    Preheat waffle iron according to manufacturer’s directions.

    In a medium bowl whisk together the flours, soda, baking powder, salt, and sugar. In another bowl beat together eggs and melted butter, and then add the buttermilk. Add the wet ingredients to the dry and stir until combined. Allow to rest for 5 minutes.

    Ladle the recommended amount of waffle batter onto the iron according to the manufacturer’s recommendations. Close iron top and cook until the waffle is golden on both sides and is easily removed from iron. Serve immediately or keep warm in a 200 degree F oven until ready to serve.

    Recipe courtesy of Alton Brown, 2005

  34. Eventually all humans will be created in labs, there will no longer be a need for women to get pregnant and give birth.

  35. If I only had a brain. Does this stem cell brain have electrophysical activity? EEG? EP’s, AP’s, EPSP’s?
    How about synaptic communication?
    I really curious at what stage of development these neurons support consciousness. How many neurons does it take?

  36. So they can do this but still no cure for cancer or HIV? Hmmmm

    • There have been huge strides in the past 20 years in treating both those things because of technology like this. The cure for cancer or HIV isn’t going to be all at once, it’ll be gradual and there’s been a lot of progress made.

  37. Oh great, people that are not from people!

  38. Mouse from mouse stem cells.
    Human from human stem cells.
    Don’t conflate.

  39. God isnt real. This is a place of science. Please take your fables yo the fox news boards.

  40. How the hell can this be a good idea? Surely there are other ways to determine the causes and solutions to early pregnancy loss.

  41. Very impressive. A bit scary too, but very impressive.

  42. Man says to God: “We don’t need you, we can now create life on our own”. God responds to man : “OK, But get your own dirt!”

    • Exactly. God created us in His image and man today wants to interfere the image of man. This will be judged one say us humans.

  43. This was actually already accomplished by researchers within the US government over 40 years ago. To me it seems rather silly… humans are silly… always trying to control everything, but really, what does it matter? The order of nature depends on illness and death. That’s just the way it is. Trying to force control over the natural ways and realities of the universe is not only egotistical and misguided, but is doomed to failure.

    • “The order of nature depends on illness and death” is an easy thing to say to somebody else but I doubt you would want to be told that when one of your close family members died. Especially when it is from something society could do a lot better to prevent.

  44. Horrible. what for ? Stoooooppp!
    Humans are the worse. Why would you create a life like that? What for ? Stop ✋disturbing the nature of life.

  45. Exactly. They can do this but not find the cure of cancer huh. This is a Horrible world with horrible people.
    All about money.

    • Stem cells from an embryo can cure cancer. Using animal embryos to study stem cells is a lot better morally than using human fetuses imo. What’s the difference, ethically, between this and just testing on an animal that was born naturally?

  46. These comments are ridiculous these aren’t babies. There was no fertilization of any egg these are just stem cells being programmed to make organs – copies of organs that the cell memory already contains blueprints for in their dna. I’m sure you people are against transplants as well as organ donating too? When it comes time that research likes this saves your life or your children’s when it’s applied to whatever condition y’all may get in the future or already have I have a feeling your morally righteous holier than thou facade will be tossed out the window… God saves those who save themselves I think is the phrase. Wasn’t too long ago that religious types thought all surgery was the work of the devil… that’s why research and science will always be secular lest it fall victim to fantasy, prejudicial ignorance, and closed minded fallacy.

    • HIstory tells a different story | August 28, 2022 at 12:54 pm | Reply

      Another fallacy… much of science was born out of Biblical thinking and thinkers. Even the establishment of hospitals was established by Christians. Get your facts straight.

    • Nailed it on the head Chris! People seem to forget that a person or animals brain consist of memories, too. until science can replicate the exact memories and experiences in a brain I don’t think we’re “playing God”

  47. Why can’t u let the world b try 2 fix wat we did dnt try 2 b god I am none religious an you are all stupid using science like this

  48. The intentions are wonderful. The actuality is wonderful. The implications are rather staggering. Some people need to thoroughly think through the ethics of this, when and if its applied to humans. This and robotics. There will be so much possibility for abuse, for wrongful use of this.

    People are against abortion–many more may liken this to that, and be against it. It’s a life form.

    Yes, YOU all are doing this for the greater good, for organ transplants and saving lives, even perhaps my own one day. And we should heartily thank you!! But first, there should be a discussion of ethics. Some scientists and leaders who don’t care about ethics may use this for evil.

    • Spud McCathern | March 9, 2023 at 9:13 pm | Reply

      Good points. I would prefer the usage of organoids, or finding ways to expand the VSEL (Very Small Embryonic stem cell like cells) population that exists in adult bodies. VSELs have been found in many tissues, in a small amount. They are pluripotent, but proliferate very infrequently. Their numbers decrease as you age, and their numbers have been correlated with lifespan in mouse models… Researchers managed to perform an in vitro expansion of VSELs using UM-171 (An aryl hydrocarbon receptor antagonist) to stimulate proliferation of these cells [2]. Resveratrol is also an aryl hydrocarbon receptor antagonist. Researchers have also demonstrated that resveratrol increases expression of pluripotency (Oct-4A, Nanog, and SOX2) [1] markers in serum derived cells. It is not much of a reach to infer that these pluripotency markers were expressed by proliferating VSELs in serum. It is possible, but unlikely, that Oct-4A, Nanog, and SOX2 would be expressed in some other cell types that don’t exist in the blood. Any such contributions from such cells to the serum profile would be insignificant.

      Links to papers:

  49. The Modern man-made horrors beyond my comprehension continue

  50. God bless you I lost the bet with God now I’m going to go buy a pack of cigarettes…God doesn’t want me smoking it was a carrot to help me decrease my smoking habbit.

  51. Freaks trying to play God for other freaks who think they are God, ie Fauci

    • How does fauci think he’s God, is it because he headed the CDC, an agency tasked with saving lives? Do you think God just wants the sick and elderly people that can’t even buy necessities without fear of death to just fend for themselves and if they die they die?? By the way, if you answer yes to the last one you have no right to call yourself a Christian and are a garbage human being.

  52. Magdalena now put them into a mouse and see how it goes.

  53. Am I the only one staring in horror at the potential this has to become a really really bad thing?

    • William Beglen | August 28, 2022 at 3:34 pm | Reply

      No. Most of us know, religious or not, this is unethical. I hope it’s the law to euthanize them before the last trimester. We don’t need “mouse monsters” that breed every couple months and have 10-30 babies. These progressive radicals in the scientific community, ruined the real science. They destroyed the world, playing “God.” We just haven’t had a big enough disaster happen yet. We will suffer badly.One way or another. This could be it.

  54. This isn’t news…Biden was born 79 years ago

  55. Its sad that closed minded, under educated & self righteous people have to make your work seem evil.. how do we ever learn anything? Science isn’t always pretty, but all the same, necessary for the advancement of mankind as a whole. — at least they are working with mice (which we have dominion over according to the bible)
    I think this is a great step in our understanding. Keep up the good work, & don’t let the naive make you second guess yourself.

    • William Beglen | August 28, 2022 at 3:41 pm | Reply

      Your comment is “naive” in itself. Are you bipolar? Or, have a multiple personality disorder? Not judging. Just an observation. You put it out there. Boost fake ass pseudoscience people’s egos. While also boosting yours. Are you a child? Sorry if I went off on you. Ignorance is not bliss! Not when unethical stuff goes on. Progressive pseudoscience is just as bad as a religious cult! It all communist footnotes carved on tress in Siberia. Total fairy tales! Even the Russian people know, pseudoscience is fictional crap.

  56. So what are you going to do with this as of she’s? Keep it locked in a cage for experiments?

  57. This is definitely end of world s***. This needs to end now. This is Satanic and against God. We will all surely burn for this if this is allowed to continue

  58. This is another way to leave God out of creation. You do not know what you are creating or how you will control it.

  59. William Beglen | August 28, 2022 at 3:03 pm | Reply

    Unethical. It’s similar to my theory on how to properly do sexual reassignment, at a very young age. Could get me rich. Could also get me killed. And If there’s a Hell, aren’t you a little worried about it? Thankfully, yours is a mouse embryo. Just to understand early trimester pregnancy miscarriage. I hope you have to euthanize them, by law, before it can live on it’s own. Even clones are unethical. They share a soul with it’s original self. Twins even share some traits like however, they are natural births. The world is crazy right now. These unnatural “human” births could cause something terrible to happen. Just like a horror movie. Please kill those things after you study them. Besides, who wants a terrible rodent/human hybrid running amuck?! We have politicians who are like rats. Study them! 😂

  60. Fake news! Just more of Evil Dr Fauci’s plan for world domination. The only people you can trust are folks who have dedicated a full weekend mostly sober researching this witchcraft. Scientists think they so smart. I bet you them there cells are chinese.

    • The CDC is a more reliable source than Alex Jones. Nowadays, anybody can just view things on the internet that agree with what they already thought and ignore everything else. Which is what the COVID conspiracy theorist do. It’s a shame that somebody’s opinion based on absolutely no facts is considered equal to scientific research studies. COVID has SUFFOCATED over six MILLION people, anybody that doesn’t seem this as the tragedy it is either isn’t looking or doesn’t care. Anybody thinking about saying something smarta-sed to me needs to know that whatever it is, you probably aren’t original. I bet when your close family members get it you’ll change your tune awfully quick…

      • I’m 27 and my dad died when I was 20. My mom has cancer and nearly died with COVID despite only leaving the house to buy food. Don’t talk about respecting life if you’re complaining about wearing a mask or getting vaccinated.

    • Welp the idea just occured to me that the original comment might’ve been making fun of people that sound like that, if so I admit it, I looked like an idiot with my tirade lmao

  61. William Beglen | August 28, 2022 at 3:11 pm | Reply

    😆 “Blade runner” Exactly. Kill them before you decide to let those monsters roam the Earth. Most of us don’t like when people play “God.” We will eventually suffer. I’m not a “Bible thumper” by any means. It’s a huge chance of creating something that can breed like mice. 10-30 offspring, every couple month! I human size “mouse monster.” Hmmm… that would be just as bad as space aliens taking over.Please, keep your head together. Euthanize them before the last trimester!

  62. Godzilla is born !!

  63. Please so sad that this Scientists use their brilliant brains in playing God. Instead of looking for the cure of Cancer, Diabetes, Alzheimer’s and some many other sickness we don’t a cure for it some many people suffering,please use your brains to better the world and to those who already suffering from sickness that we don’t have the answer for it

  64. This is the most frightening article I’ve ever seen. We’re into playing God now?

  65. Way to many of these running around in human firm now, no substance!!!

  66. One day you’re going to create something that’s going to eat is all up and no way to get rid of it:(

  67. Can Professor Magdalena Zernicka-Goetz join the scientist working on bringing back the extinct animals?

  68. It is also wrong and unNATURAL!!! It goes against logic and reason. JUST BECAUSE IT CAN BE PROVEN DON’T ALWAYS MAKE IT RIGHT!!! STAY WOKE!!

  69. Scientists are not creating life, they are taking components from the living, be it human or animal. Only God creates life. Scientists are merely recycling when they take stem cells from humans or animals and make “something” with them.
    This article got me looking at other articles about this great controversy of stem cell research.
    I found one from 2012 that said scientists took cells from human corpses and reprogrammed them into stem cells. They are using this research to study the processes of the brain to better understand autism
    and schizophrenia. They believe these come from problems in brain development. Can you imagine how much further along they are ten years later?
    There are fantastic, wonderful breakthroughs with stem cell research; mental health, aging, diabetes,HIV/AIDS,heart disease….but there’s a door that says


    Mankind has already opened that door, walked past the point of no return, and with blatant disregard for ethics, morality, and religion, in terms of rules of conduct, scientists continue to open doors that say DO NOT ENTER,
    and walk further and further into areas they have no understanding of and ability to troubleshoot, areas like raising the dead, creating a society of lab grown, and cloned, people,for lack of a better word at this writing.
    What about these lab grown people’s emotional developments? What about the necessary connections in the body for emotional development? Will they be missing from this new stem cell thing?
    I’m scared for future society. I hope all goes well, but how can it when the people that are doing the work don’t even have a moral compass, or a belief in Our One True Creator, The Father Of All Living Things

    • “Can you imagine how much further along they are ten years later?” Sounds a lot like a slippery slope fallacy. You’re connecting what’s happening now to something that hasn’t happened and using it to imply that if this is happening then that WILL happen. Just because something can happen doesn’t mean it will. In fact, if you expect something to happen a certain way, it usually doesn’t.

  70. Knowledge without wisdom is extremely dangerous, and the road to hell is paved with good intentions!

  71. Gaetano Montante | August 28, 2022 at 7:51 pm | Reply

    Wow. Wow, Wow! I am astonished Both for the great achievement of discovery and also… for the extreme fear and vitriol shown in many of the comments below.
    Why is it that some “subjects of study” should never, ever be approached with simple questions like Why and How? This obstinacy of some rather intelligent people (like the ones reading this article!) towards “remaining” ignorant never ceases to amaze me.

    • I know, this technology could save someone’s life. Some of these comments are just awful. I bet they would change their position if one of their loved ones needed an organ.

  72. So question… these stem cells.. they come from a developed cellular growth that was the result of a sperm and egg union ? Correct? So all of the dna required for development is already there and they just have it an ideal environment for it to do what it’s already coded to do.

    • Yes! This doesn’t mean people are “playing God”. Some of these commenters seem to think scientist and doctors should let sick people die and do nothing because it might offend God. Smh at people..

    • Earlier the Better | August 30, 2022 at 7:01 am | Reply

      You are referring to Chromosmes/DNA; If so, Where did G come from? Was born in different places at different times?

  73. Golden has a point. Just because we can doesn’t mean we should. We’re going way too far and involving innocent unsuspecting lifeforms to play around. I’m an atheist and typically pro science, but enough is enough. The human race needs to come to an end, not figure out how to beat death. It isn’t a puzzle to be solved, we’re only meant to flow alongside it. The problems people have during life and even in the womb are natural to the line of work we’re in ..being human. We’ve done most of it to ourselves and it’s time to accept our limitations, go back to nature while we can and move on from this quest to supposedly fix everything we’ve caused. Nature will take it back.

  74. What purpose will this serve. You have probably crossed a line that you shouldn’t have

  75. Sounds like they’re having fun playing God. I think stuff like this is why God destroyed the earth with the flood.

  76. We’re doomed. This is it.

  77. All these comments about GOD not existing have every little time to get their headed straight. We’re And the cusp of it being too late. So I suggest you take this time to head your head straight!! Stop blaming GOD and religion for your lack of sence!! I will pray for you , and quitbusing AMERICAN as a name everyone knows your clearly not!! O , wait let’s blame them cause your uneducated!! Or you just have never picked up a book!! Clearly not the GOOD BOOK!!!

  78. God’s master plan is exposed for anyone to see, if they study it long enough. Scientists are mearly monks, toiling to find the questions to ponder. This new creation asks:how many monsters will we fashion, and how badly will they hurt us before we create our first Angel?

  79. The aborted fetus was discarded, now the stem cells are used to grow cells through extraembryonic cells talking to other cells and growing from,that point on. This doesn’t seem like Frankenstein but science from discarded stem cells that can be utilized for the profitability of new possibilities within the mother who is having complications. If we can save a life I am all for it. About growing organs for human transplant well I guess we can really call the brain dept. at the hospital now.

    • Yes, people with things like cystic fibrosis or diabetes or heart failure could benefit a lot. If God opposes this it would be sort of cruel on his part, send like a bit of a power trip

  80. The mindblown reactions of prolifers are going to be hilarious!

  81. Smh at zealous pro religion botnets.

  82. Satan was never satisfied serving God, he wanted to be God! Only thing is, he can never be creator because he always has to start with something God made! He’s an imitator not a creator and that’s the same with man or woman who wants to be God. We are more than mind and body. We are also spirit and that can’t be created. It is God breathed!

    • Earlier the Better | August 30, 2022 at 5:51 am | Reply

      1000 years from now, Researchers will be able to take molecules, make DNA…make chromosomes and Create a NEW Animal, Plant or Coral Reef !

  83. Lord Havenshire the 1st | August 29, 2022 at 4:54 am | Reply

    What came first the chicken or the egg?
    The Black Plaque came from mice and their flies.
    Imagine what mutated mice will bring!!!

  84. Hey mad scientist.
    You got anything to get my MOJO

  85. You are playing God. Leave it alone.

    • If “playing God” can save someone’s life, than I would imagine God wouldn’t want his creation to suffer unnecessarily.

  86. This is the beginning of the end. Be prepared.

    • The world has been going to end tomorrow for 2,000 years now, according to religious zealots, and we’re still here. I don’t get why some people aren’t paying attention to the REAL disasters of the past couple years and keep going on about some fictitious one.

  87. 2022 and still all this “God” talk. The plague on this planet causing all of ours issues as humans is called religion. The number one reason for war and death since the beginning and of time. Holding on to these thoughts and feelings from thousands of years ago is one hundred percent why people don’t get along. Why racism still exist, why slavery still exist. You people are the problem, not science.

  88. Reinventing Myself | August 29, 2022 at 7:35 am | Reply

    To many informalities being synthetic leads to normal matabilation process to be inert. There is no imunity to anything that is not soluble and be naturally absorbed and matabilation with a Effecient processed. With a mind off its own you could be harvesting a pathological species that will consume anything foreign with extreme prejudice and a a necessary supplement We will be it’s food with no antidote. It will be catistrofic can’t believe it’s being allowed we can’t even control naturally occurring virus you created one with a brain 🧠

  89. This is awesome!! Keep up the great work! So many possibilities open up through research like this! This is too cool!!

  90. The problem I see with these discoveries and new understanding of all that must go right for a successful pregnancy is all entire community of eugenicists who are simply looking for the single point of failure in the process that they can use to terminate an early pregnancy. Can they induce failure with pulsed magnetic frequencies? What frequency will interrupt proper timing or expression of any of the critical processes? Is there a harmonic frequency which can be achieved by EMP or radio transmission which could mechanically shake apart or otherwise disrupt the pregnancy in its earliest stages? Can these frequencies be transmitted in mass with existing technologies like 5G or less or could they simply modulate the existing 60 HZ field field in home wiring? All tech can be used for good or evil, it’s a matter of who is doing the research and how that knowledge is used to develop the next generation of technology built on that research.

  91. If only these brilliant minds focus on resolving problems cause by previous scientific discoveries (e.g. the harvesting of carbon that later created global warming and weather disasters). History has proven many times that when a unnatural scientific experiment go against nature, disaster follows.

  92. They should grow them without brains so we can harvest the organs

  93. So…this headline is pretty much fake news. “without an egg or sperm” but how do you think they got the stem cells? It either came from tissue or an embryo, both of which started as a fertilized egg. Cool story but the headline tried to make it sound like that are gods. Lol

  94. God is good.

  95. I think we are over populated as it is. What we need is to stop all these East Indians and Chinese to stop having kids any country that has more than a billion people. That would solve half of the world’s problems and to solve the other half we need to get 2 billion people off this planet just so it could start healing 4 billion to have enough reverse the amount of damage we have done.

  96. Eddie Finger MaButhole | August 29, 2022 at 2:14 pm | Reply

    Do you think these embryos would form into edible beings?

  97. Karen Pickering | August 29, 2022 at 10:38 pm | Reply

    This is great research and all, I applaud you all and wish for you all the success there is to be found in this evolutionary effort. Could someone take a moment to help a dear lady I know who has been waiting in agony everyday for a hip that seems to illude her. Minutes are like hours daily here. I cry for her when I leave her. Someone please read this and help her! *all the love,

  98. @ Beglen

    Re “The world is crazy right now”

    Not just “right now” … and…

    Everyone “knows” the world is crazy (which always “conveniently” means the world/OTHER people, usually the governing authorities, are crazy but not they themselves, of course). Yet no one typically offers an good explanation on why that is.

    Have you ever wondered WHY the world is crazy? How do you explain it intelligently? Do you have a coherent explanation for the craziness of the world that makes sense (religious fantasies are obviously excluded because they only “make sense” and are “valid” to fantasy lovers but never to reality-based truth-seekers)?

    The WHOLE big picture (not just a part of the big picture) that makes up the human condition, that explains the craziness of the world (if you ever genuinely wondered WHY it is that the world is crazy), that describes human conduct over millennia is the hegemony of the 2 married pink elephants in the room and has never been on clearer display than with the deliberate global Covid Scam atrocity — see “The 2 Married Pink Elephants In The Historical Room –The Holocaustal Covid-19 Coronavirus Madness: A Sociological Perspective & Historical Assessment Of The Covid “Phenomenon”” ….

    (CAVEAT — only read the 2 pink elephant article if you’re GENUINELY interested in the truth and therefore “CAN handle the truth” …)

    • If you think COVID is a scam go visit your local hospital’s COVID ward. No shots or mask. My elderly mom nearly died and had to have months of oxygen and physical therapy despite being boosted and masked and only getting out to buy groceries.. because of stupid whackjobs like you. THAT’S the truth and it’s far more horrific then whatever garbage conspiracy theory you’re going on about.

      • Why didn’t you just go out and get your elderly mothers groceries for her? We all need to stop living in fear! Whats the point of life not lived? Man is appointed to die.

  99. Earlier the Better | August 30, 2022 at 5:23 am | Reply

    Now Genetics has chosen a great new path; Not just for transplantations, even for transfer of features safely among 2 species at their embryonic stages. Decades or Centuries from now, we should get lost abdominal muscles and their control by brain of rhesus monkeys. They are seen automatically jumping onto kitchen counters without any planning. Rabbit meat is eaten by us. So, turning it into the size of Cattle or even Elephant will be great. Elephants are sometimes agressive. But, if we can make Elephants as small as Rabbit, it will be a great pet in the houses/backyards !

  100. Earlier the Better | August 30, 2022 at 5:47 am | Reply

    Anyone has turned Atheist on Reading this Great Accomplishment and also Reading the plentiful comments here?

  101. Earlier the Better | August 30, 2022 at 7:06 am | Reply

    People have Chromosomes; Plants have Chromosomes. Even Corona has DNA. Next step for Scientists is to create NEW DNA and a Brand NEW sedentary plant or moving animal from it …Which will NOT be far off. Science has progressed too much. Didn’t we Destroy 2 Japanese Cities just like that?

  102. Earlier the Better | August 30, 2022 at 7:40 am | Reply

    The great Chromosomes ! 2-month old Rhesus Monkey Infant jumps & climbs wall. How many years do Human Babies have to take to start to even walk? We have Brains, but we have lost too many features also. Remember that (Look at Alligators’ teeth for funny example). They fused this week 1 mouse chromosome to its other chromosome. Nature does not allow it. It takes millions of years scientists say for some small useful? /Not useful? change to occur.

    • Earlier the Better | September 2, 2022 at 3:05 am | Reply

      Think of Axolotl that can Regenerate all of its lost Body Parts, including its Brain; Think of Tardigrades that can survive under extreme pressures (both high-in deep sea and low), southpole, exposure to extreme temp, air deprivation, radiation, dehydration, and starvation.

  103. Earlier the Better | August 30, 2022 at 8:09 am | Reply

    SciTech is Super Supreme, starting with Computer and Internet. Chromosomes/DNA is the Origin of all of it, though. G. Beliefs have NOT Created Good at all. Wars are there, even Now in 2022. 2 Japanese Cities Destroyed? Psychologists? They do not say why there are Mass Shooters?

  104. Earlier the Better | August 30, 2022 at 3:08 pm | Reply

    My serious question is, Can you make people young? Have you injected such embryo’s cells into Adults and seen the results? They are like Treasury !

    • Earlier the Better | August 31, 2022 at 4:05 am | Reply

      Always try in mice first, (just like Vaccine makers are trying with Corona in mice); Various species of mice live 1, 2 or 5-7 years at the most.

  105. We live in a sick sick world

  106. Earlier the Better | August 31, 2022 at 3:54 am | Reply

    It is said that U.S Life Expectancy has fallen from Near 80 to 76 in these couple of years already because of COVID. So, it is high time that various cells or parts of them of that synthetic mouse embryo are injected into mice of origin and checked for their longevity. It will be nice to have several identical cloned mice are made to be born to be injected into for hastening the procedure.

  107. Joshua Klopfenstein | September 1, 2022 at 11:31 am | Reply

    Without sperm and egg they say… then the first sentence says it came from mouse stem cells…. and where did the stem cells come from? oh yeah sperm and egg… I’m not impressed… so you mean a living thing came from stem cells like they always do? wow! … except this time we didn’t start with the sperm and egg …we started with the stem cells… that yes came from sperm and egg… man still can’t rival what God created and the way he put things in motion.

  108. Digital Bookworm | September 2, 2022 at 6:50 am | Reply

    The religious are always saying “life begins at conception”. Yet here they are jumping all over this scientific breakthrough even though there was no “conception” involved.

  109. So, now we can create a race of SUPERMEN,who can be programmed to do whatever they are told.
    Hitler would be pleased.
    SIEG HEIL ☠️

  110. They are going to make an alien one day like in all the science fiction movies. Scary😱

  111. This sounds like a miracle, but it also sounds wrong. Should we be creating “synthetic” life? Especially, just to part it out? I mean, whether it be in a womb or a dish, if it creates a heartbeat and brain, is it not now considered alive? A life? I think we are crossing dangerous boundaries.

  112. I’m an agnostic and a scientist. This reminded me of a Woody Allen film (“Sleeper,” 1973). In the year 2173, you’ll get into a porta-potty looking device to get all your climax needs. Alone. I guess guys like this bunch will be the ones in charge of perpetuating human idiocy on this earth.

    This thing won’t stop any time soon. May we live in interesting times!

  113. I’m sorry instead of creating more babies how about finding cures for diseases this synthetic stuff is crazy
    God creates life and ends it not us.
    It’s not right

    • Earlier the Better | September 5, 2022 at 4:15 pm | Reply

      Harvard Medical School Professor David Sinclair says, “Getting young is eradicating all diseases”. That is rather than using medicines which are really not that worthwhile. The Mother Mouse saw better than its offspring and also regained its lost Memory Completely; Reagan’s last 2 Decades were with Alzheimer’s. On one fine day, such issues will be fixed with a shortcut. It may take several years, because we cannot meddle with human bodies, like it is being done in Mice.

  114. Great, now we can have an endless supply of slave organs, and meat to throw at our wars, and dangerous jobs!

  115. Stop playing GOD!!!

  116. Earlier the Better | September 4, 2022 at 8:09 am | Reply

    To hurry up, do not use tiny mice, eventhough tissues and cells are observed under microscopes in the lab. Resort to a Mega Project of 100 Hornless or Dehorned and Well healed Goats in a nearby Farm. Reason is that we can have better view of any changes visually in Bigger Hoats. Also, We need the expected excellent results ASAP. Mark the Goats and also use Facial Recognition App. Have an additional smaller lab at the Farm also with Surgeons/Researchers etc. Why 100 Goats? Cells of Various Brain parts of their Synthetic Embryos should be injected into respective Brain regions of respective adults. While Human Infants only swiftly keep moving their hands and legs constantly lying on their backs, Infants of some animals keep jumping swiftly, while their adults stay calm. So, Observe Behavior of Goats after receiving their synthetic embryo’s brain cells. Do they behave like Baby Goats? Also, there are various Body parts in Synthetic embryos. Use Cells of them to their Respective Adults and see any resulting biochemical, physiological and more changes. Will there be any Anti-Aging Effects?

  117. Earlier the Better | September 4, 2022 at 4:38 pm | Reply

    Genes responsible for ‘Forever living’ Immortal Jellyfish (Turritopsis dohrnii) are now Identified; It Intermittently switches between its Adult and Larval stages; When stress of being an Adult becomes too much for it to bear, it simply turns back the clock & becomes again Juvenile/Larva.

  118. Oh boy more people with to much time and money playing god. Let’s see what they make that will destroy humans.

  119. Democrats are currently trying to figure out how to get them to vote.

  120. Earlier the Better | September 5, 2022 at 3:16 pm | Reply

    Old Mice are Turning Young again in Lab of Harvard Medical School’s Molecular Biologist, David Sinclair; Try to read what is happening; Olden Days are gone Forever !

  121. If stem cells can actually grow organs without destroying a life, that will be real progress. Think of all the people in need of organs that can be helped by stem cells rather than transplanting organs from another human.

  122. This is what Morpheus showed Neo in the Matrix. Quoting from the move, in the future humans will not be born, they will be made. There will be fields and fields of humans being grown in huge capsules. Welcome to The Matrix y’all ready to go down the rabbit hole?

  123. Concerned Citizen | September 6, 2022 at 5:13 am | Reply

    There are significant ethical questions that must be raised in this “research”. Once life is formed and research is completed, what happens to the life? What sustains an nourishes the life? Is it a mother? Will life be implanted in any gender? Key development occurs in a womb of a living being whether human or animal. If fostered in an artificial environment what will this unnatural life form become? what shapes its existence? If ot will not exhibit the behaviors desired by its creatirs what will be its fate? Additional experimental research, harvesting or organs/tissue to experiment on something different, cyborg tissue cultivation or killing it? For the future there are many questions that need answers. In your think tanks and meetings, have people on all sides to appropriately address the ethical and moral questions that should arise in this endeavor. It will be much needed. Because we can should we?

  124. Secular Absurdist | September 6, 2022 at 7:37 am | Reply

    This is so cool! I love science. It’s incredible what humans can do when they are educated. It’s really sad to see all the uneducated religious people in the comments proselytizing their dead/non-existent god. Don’t y’all have a bible to read? Or Quran? Like just keep to yourself. Nobody cares about your dumb sky daddy. World is better off without religion.

  125. Earlier the Better | September 14, 2022 at 1:30 pm | Reply

    They have been Trashing SciTech by Stomping it under their Feet; DNA is God; The Smaller one DIED 1-2 yrs. Ago, When Owners were on Vacation by Falling Down ; “Cute Baby Luna And Sister Tiny Nina Have Fan And Playing Swing Together”.

  126. Earlier the Better | September 20, 2022 at 1:38 pm | Reply

    Genetics has awful lot ways to be Advanced. This will lead to the Pinnacle of Acheivements immensely helping Each & Every Human. Not just Vaccines for all….Their OWN Embryos for all humans using their Skin Cells->Stem Cells. Need not have Infants grown from them. Organ Transplantations from Person to Person or even from pigs as done recently should become History. Try to Stop Rare Genetic Disorders, Ageing (Progeria) etc., using this technique. As I said, Genetics progress can be accelerated. Not only do those Cheetahs have that Interesting Skin Design. While watching on youtube, I came across fox species displaying similar skin design also. How? Try to locate the Chromosomal/DNA Mystery behind that feature. It should be easy !

  127. Earlier the Better | September 20, 2022 at 1:52 pm | Reply

    On Wild Life of Africa, even babies of ostriches and some fox species have that cheetah’s skin design. Exactly same.

  128. Earlier the Better | September 22, 2022 at 3:00 pm | Reply

    This Report is dated Aug 27, 2022 and Today is Sep 22, 2022; Obviously this report has immense potential for Living beings. No one working in those fields discuss publicly from time to time? We have heard of mouth to mouth and Cardiopulmonary (CPR) resuscitations. We constantly hear about Politics. Nothing about use of these new synthetic embryos. There must be immediately a central place (industry) which sells to interested labs a mouse, rat, rabbit or goat and 10 to 100 of their living synthetic embryos. Can just dead be immediately reversed using these synthetic embryos? OR Can an animal made unconscious with some chemical spray be woken up ASAP using these synthetic embryos? Synthetic is a wrong word, actually. Very misleading. There must be a million ways they are helpful. But, what are they? Collect the Data ASAP. There must be daily discussions of them by the public too, just as info. on politics, sports etc., etc. are constantly spread around

  129. Earlier the Better | September 22, 2022 at 3:19 pm | Reply

    What bothers me is seeing conjoined human twins being born and growing up even into youthood. A despair for them and their parents also. What happens inside the uterus? Can we not work in that area using the animals for now? There are so many animal species of various sizes at our disposal. Are they there only to eat? Can’t we stop that misery?

  130. Earlier the Better | September 22, 2022 at 3:32 pm | Reply

    Obviously, so many things can be done at embryonic stage. Spider monkeys are seen hanging from a branch using their tails. Other animals have useless tails. At the most, some do use them to push away flies nearby. Can’t we create spider monkeys without such tails or other monkey species with such a tail? There must be a shortcut for embryologists and geneticists. Such findings will attract interest of the lay public too.

  131. Earlier the Better | September 22, 2022 at 5:27 pm | Reply

    How many MALE Oxen Suffered under the Sun? WHY? How come Vivek_khakkas Ananda’s India is Largest Exporter of Rice in the world? India has 2nd Largest world Population. Don’t Anyone know it? Which Rogue STOLE AND Exported? Export ONLY Scitech Related Stuff, NOT Grains.

  132. Earlier the Better | September 24, 2022 at 3:22 am | Reply

    Using these Synthetic Embryos should provide the answer for the following question that is raised below ! I saw a couple of Kg weighing Adult Rhesus Macaque, without approaching from a distance at a great speed or any planning, jumping onto a 6′ Smooth Cemented Wall. I read yesterday that they are going to map the Entire Human Brain with ~86 Billion Cells, Connected with one another altogether trillions of times. Compared to that Macaque, We have to jump onto a 60′ feet wall, because of our height & weight difference. What deprived us of that ability? Either Our Brain or Our Abdominal Muscles? We can’t do 6′ even without a bamboo stick, etc., etc.

    • Earlier the Better | September 24, 2022 at 3:32 am | Reply

      2.45 meters, yes…but cannot land on the wall…Fly over onto a sand bed only !
      The high jump world record is 2.45 meters (8 ft 0.46 in), by Javier Sotomayor of Cuba, who achieved this height on the 27th of July 1993 in Salamanca (see High Jump Record videos). Sotomayor also holds the indoor world record of 2.43 meters (7 ft 11.67 in).

  133. Earlier the Better | September 25, 2022 at 4:38 am | Reply

    Synthetic Embryo should not be an end in itself. A FEMALE Synthetic embryo should be put back into the UTERUS of the SAME FEMALE and ensure it is born as a FEMALE first. Once such experiment is successful, MALE Synthetic embryo should be put into the UTERUS of its Original MOTHER and allow it to be born. If these do not work in mice, try some other animal such as Rat, Rabbit, Goat etc., We have awful lot of animals. There should be an immense progress with extraordinary efforts in this field ASAP. (This phenomenon is specific to animals only. We can cut off a branch of a plant and let it grow in the soil again. In nature, Seeds are formed using the same flower or flowers of 2 different plants).

  134. Earlier the Better | September 25, 2022 at 4:50 am | Reply

    What is the use of Synthetic Embryos? They should be used to dilute the effects of Ageing or toxic effects of chemicals that the animals were deliberately exposed to. It enhances or makes it fast. It will be great if 10, 100 or even 1000 synthetic embryos of the same animals are made in a central location for use by labs. As mentioned earlier, death is prevented by mouth to mouth or cardiopulmonary resuscitations. Can ALREADY DEAD be immediately reversed back to life by using multiple synthetic embryos in some way? Since it is not a joke to make a synthetic embryo, there should be a group of specialists making them elsewhere for use by various labs in the world. If insulin making cells of pancreas are lost, let synthetic embryos help it.

  135. Earlier the Better | September 25, 2022 at 5:11 am | Reply

    Already we have some identical twins of SAME age in nature. Unfortunately, also even conjoined twins. What we need is an Somewhat Aged Adult and an Infant of the SAME Animal. Efforts should be made ASAP, because the yield is imagined to be really great. Humans have come up with light bulb, train, car and plane. For 2022 and beyond, this should be the much craved endeavor hereafter !

  136. Earlier the Better | September 25, 2022 at 9:41 am | Reply

    Synthetic Embryos are very young and hence must be extremely useful in studies for treating Progeria with no cure currently and in Juvenile Diabetes. Progeria may be rare, but does occur in Humans in their first year of life itself, even though they appear normal at birth. Mutation in a Single gene, LMNA producing Abnormal form of lamin A protein (called progerin) which makes cells unstable leading to progeria’s aging process. Is child itself responsible, mother or father? So, Whichever trash is responsible and is loaded must be taxed. Parents and child should be consoled for their unexpected misery.

  137. Earlier the Better | October 5, 2022 at 4:45 am | Reply

    Do/Can Synthetic Embryos gain Consciousness too? What is needed for that to happen on one fine day? Is Exchanging of Locations of Synthetic and Natural Mouse Embryos (preferably, say 5 days old Natural Embryos) help in achieving that feature? They may be with same mother or of different mothers, who knows? For example, Take Bird Eggs that grow almost completely outside their Mom’s womb until hatching.

  138. Earlier the Better | October 6, 2022 at 2:31 am | Reply

    Next Level of work has been done already in a different fashion by Sinogene Biotechnology Lab now using Somatic cell nuclear transfer, the same laboratory technique that was employed to create Dolly the sheep, the world’s first-ever mammal clone over 2 decades ago; Beagle Dogs are half the size of (Endangered)Arctic Wolf. Both of them belong to the Genus, Canis though. Nucleus of Skin Cell of Wolf was removed, Injected into Oocyte(Cell in Ovary of Female that undergoes meiotic division to form Ovum/Egg Cell) of Female Dog after removing its nucleus. After Mom Beagle Dog got this in its Womb, Wolf Puppy was born to that Surrogate. After Failure after Failure, 7 Beagle Dogs were impregnated with 61 embryos formed from such Modified Cells and 2 Clones of Puppies were born 103 Days apart to 2 of those Surrogate Moms.

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