RNA News

New Delivery Technique Enables Rapid Treatment for Inflammation

January 20, 2017

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New Technique Enables Rapid Delivery of RNA to Treat Colon Inflammation

A team of engineers has developed a new RNA delivery technique that uses short bursts of ultrasound to efficiently deliver RNA into cells, reducing colon inflammation. MIT and Brigham and Women’s Hospital researchers have demonstrated that they can deliver strands of RNA efficiently to colon cells, using bursts of ultrasound waves that propel the RNA […]

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Yale Scientists Track the Development of the Embryo

January 2, 2017

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Researchers Track the Development of the Embryo

Scientists at Yale University have discovered a way to track the precise bits of RNA that control the development of the embryo into trillions of specialized cells in a living animal. The new assay, tested on the genome of zebra fish, allows scientists to pinpoint function of myriad of signals activated after fertilization. “The problem […]

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MIT Biologists Reveal How lncRNA Helps to Control Cell Fate

September 12, 2016

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Biologists Discover How RNA Helps Control Cell Fate

New research details how biologists from MIT deciphered the structure of one type of long noncoding RNA and used that information to figure out how it interacts with a cellular protein to control the development of heart muscle cells. Several years ago, biologists discovered a new type of genetic material known as long noncoding RNA. […]

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Engineers Design Programmable RNA Vaccines That Protext Against Ebola and H1N1 Influenza

July 5, 2016

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MIT Engineers Design Programmable RNA Vaccines

A newly published study details how engineers developed programmable RNA vaccines that work against Ebola, H1N1 influenza, and a common parasites in mice. MIT engineers have developed a new type of easily customizable vaccine that can be manufactured in one week, allowing it to be rapidly deployed in response to disease outbreaks. So far, they […]

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Yale Researchers Identify RNA That Controls Cholesterol

October 7, 2015

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Researchers Identify Tiny RNA That Controls Cholesterol

A new study from Yale University reveals that miR-148a modifies LDL receptors in liver cells of both mice and humans and suppresses a gene that is critical for controlling levels of HDL cholesterol. High levels of LDL cholesterol — the “bad” cholesterol — increase the risk of heart disease, the leading cause of death in […]

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Research Reveals New Strategy to Control Cellular Identity and Fate

December 5, 2014

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A New Strategy to Control Cellular Identity and Fate

Newly published research suggests a new strategy to control cellular identity and fate, revealing that depleting or knocking out a chemical tag on RNA keeps embryonic stem cells in suspended animation. A team of scientists that included researchers from UCLA has discovered a novel mechanism of RNA regulation in embryonic stem cells. The findings are […]

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RNA-Carrying Nanoparticles Deliver siRNA to Endothelial Cells with High Efficiency

May 12, 2014

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Engineers Design RNA Carrying Nanoparticles

Researchers have designed RNA-carrying nanoparticles that can deliver siRNA to endothelial cells with high efficiency, raising the possibility of treating many types of disease, including cancer and cardiovascular disease. RNA interference (RNAi), a technique that can turn off specific genes inside living cells, holds great potential for treating many diseases caused by malfunctioning genes. However, […]

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MIT Researchers Reverse a Rare Liver Disorder in Mice

April 3, 2014

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MIT Researchers Reverse a Liver Disorder in Mice

In a newly published study, MIT researchers show that a new gene-editing technique, known as CRISPR, can reverse a rare liver disorder caused by a single genetic mutation. Using a new gene-editing system based on bacterial proteins, MIT researchers have cured mice of a rare liver disorder caused by a single genetic mutation. The findings, […]

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New Research Changes the View about the Genetics of Leukemia Risk

October 14, 2013

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New Research Changes View about the Genetics of Leukemia Risk

In a new study, researchers identified the agents that could be responsible for many leukemias without TET2 mutation. This finding could help doctors develop a course of treatment for leukemia patients. A gene that helps keep blood free of cancer is controlled by tiny pieces of RNA, a finding that may lead to better ways […]

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Better Protein Creation is the Key to Longevity for the Naked Mole Rat

October 2, 2013

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Better Protein Creation is the Secret to Naked Mole Rats Longevity and Health

In a newly published study, University of Rochester researchers show that better constructed proteins are the key to the naked mole rat’s longevity and health. Naked mole rats have what any animal would want. They live long lives—about 30 years—and stay healthy until the very end. Now biologists at the University of Rochester have new […]

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Penn State Researchers Discover the Origins of Genomic “Dark Matter”

September 20, 2013

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Penn State Scientists Discover the Origins of Genomic Dark Matter

In a newly published study, researchers from Penn State University detail the discovery of the origins of genomic “dark matter.” A duo of scientists at Penn State University has achieved a major milestone in understanding how genomic “dark matter” originates. This “dark matter” — called non-coding RNA — does not contain the blueprint for making […]

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New Findings Challenge Assumptions about the Origins of Life

September 17, 2013

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New Findings Challenge Assumptions about Origins of Life

New research from biochemists at the UNC School of Medicine offers an intriguing new view on how life began, challenging current assumptions about the origins of life. Chapel Hill, North Carolina — Before there was life on Earth, there were molecules. A primordial soup. At some point a few specialized molecules began replicating. This self-replication, […]

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Study Suggests Life on Earth is the Result of Icy Comets

June 6, 2013

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New Research Suggests Life on Earth Came from Comets

A newly published study suggests that life on earth may have started as a result of icy comets that crashed into Earth billions of years ago. Early Earth was not very hospitable when it came to jump starting life. In fact, new research shows that life on Earth may have come from out of this […]

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piRNAs Key Role in Coordinating Biological Activity

February 25, 2013

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piRNAs Key Role in Coordinating Biological Activity

A team of Yale researchers discovered that specialized RNAs called piRNAs guide epigenetic factors to numerous sites throughout the genome of the fruit fly Drosophila, where these switches work to turn genes on or off. If a genome is the blueprint for life, then the chief architects are tiny slices of genetic material that orchestrate […]

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“Proto-RNA Bases” Assemble in Water, Hint at Origins of Life

February 21, 2013

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An Alternate Theory For The Origin Of RNA

A newly published study explores an alternate theory for the origin of RNA, achieving highly ordered self-assembly in water with small molecules that are similar to the bases of RNA and possibly providing insights into the origin of the first RNA-like polymers. The base pairs that hold together two pieces of RNA, the older cousin […]

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Key Differences in Seemingly Synonymous Parts of the Genetic Code

January 21, 2013

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Arvind Subramaniam

A new study from researchers at Harvard University shows that rates of protein synthesis are affected by environmental perturbations, resulting in certain sequences that manufacture proteins efficiently, while others which are ostensibly identical, produce almost none. Harvard scientists say they’ve solved a mystery that’s nearly as old as science’s understanding of the genetic code. Though […]

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Synthesizing a Flu Vaccine Without the Virus

November 27, 2012

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flu-virion

A new vaccine strategy, which uses synthetic messenger RNA (mRNA) instead of proteins purified from viruses, could make flu shots cheaper, safer, and easier to produce. German scientists have shown that they have been able to protect mice, ferrets, and pigs against influenza. The scientists published their findings in the journal Nature Biotechnology. Most flu […]

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Atomic Level Splicing Further Establishes RNA’s Chemical and Structural Complexity

October 29, 2012

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chemical processes by which RNA carries out the expression of our genes

A newly published paper from researchers at Yale University looks at the process of splicing RNA at the atomic level, establishing RNA’s chemical and structural complexity and showing that it is capable of recruiting diverse metals and orienting them to work with RNA. Scientists at Yale University have described in the greatest detail yet aspects […]

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