PLOS (Public Library of Science) is a nonprofit publisher and advocacy organization founded to transform research communication to facilitate open access—free availability and unrestricted use of scientific research and data. Established in 2001 by a group of scientists and physicians, PLOS’s main objective is to make scientific and medical literature a freely available public resource. It operates several peer-reviewed journals, with PLOS ONE being its largest. PLOS ONE is known for its broad scope that spans all areas of science and medicine. It doesn’t focus on the perceived importance of a study, but rather on the rigor of the research, aiming to promote the reproducibility and transparency of science. PLOS journals also advocate for changes in the communication of science, pushing for open data, post-publication commentary, and more dynamic, equitable access to research findings. Through its efforts, PLOS has been at the forefront of the open access movement, which seeks to enable scientific results to be more easily shared and built upon.